512731

Paromomycin Sulfate

An aminoglycoside antibiotic containing 5 amino groups that exhibits antibacterial and antiamebic activity.

• Synonym(s): Paromomycin Sulfate, Neomycin E
• Empirical Formula (Hill Notation): C₂₃H₄₅N₅O₁₄ · xH₂SO₄
• CAS Number: 1263-89-4
• Molecular Weight: 615.63 (free base basis)
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: off-white
• solubility: water: soluble
• shipped in: ambient
• storage temp.: 10-30°C
• InChI: 1S/C23H45N5O14.H2O4S/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;1-5(2,3)4/h5-23,29-36H,1-4,24-28H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18?,19-,20-,21-,22-,23?;/m1./s1
• InChI key: LJRDOKAZOAKLDU-UMIPPVEZSA-N

Description

General description

An aminoglycoside antibiotic containing 5 amino groups that exhibits antibacterial and antiamebic activity. Recent NMR evidence indicates paromomycin binding to the A-site of 16S rRNA induces a local conformational change that suggests a mechanism for aminoglycoside action on protein translation.

An aminoglycoside antibiotic containing 5 amino groups that exhibits antibacterial and antiamebic activity. Recent NMR evidence indicates that paromomycin binding to the A-site of 16S rRNA induces a local conformational change, suggesting a mechanism for aminoglycoside action on protein translation. Also exhibits anti-protozoal properties.

Potency: ≥675 µg/mg.

Warning

Toxicity: Harmful (C)

Other Notes

VanLoock, M.S., et al. 1999. J. Mol. Biol. 285, 2069.
Blanchard, S.C., et al. 1998. Biochemistry 37, 7716.
Fourmy, D., et al. 1998. J. Mol. Biol. 277, 333.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable