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422712

Sigma-Aldrich

KN-93

InSolution, ≥95%, A cell-permeable, competitive inhibitor of Ca2+/calmodulin-dependent protein kinase II

Synonym(s):

InSolution KN-93

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About This Item

Empirical Formula (Hill Notation):
C26H29ClN2O4S
CAS Number:
139298-40-1
Molecular Weight:
501.04
MDL number:
MFCD03788201
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥95% (HPLC)

form

liquid

potency

370 nM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

shipped in

wet ice

storage temp.

−20°C

InChI

1S/C26H29ClN2O4S/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25/h3-16,30H,17-20H2,1-2H3/b6-5+

InChI key

LLLQTDSSHZREGW-AATRIKPKSA-N

General description

A cell-permeable, competitive inhibitor of Ca2+/calmodulin-dependent protein kinase II (Ki = 370 nM). Selectively binds to the Calmodulin (CaM) binding site of the enzyme and prevents the association of CaM with CaM Kinase II. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets. Has no significant effect on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
cam kinase 2
Product does not compete with ATP.
Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Physical form

A 5 mM (1 mg/399 µl) solution of KN-93 (Cat. No. 422708) in DMSO.

Reconstitution

Following initial thaw aliquot and freeze (-20°C).

Other Notes

Fan, G.H., et al. 1999. Mol. Pharmacol.56, 39.
Tombes, R.M., et al. 1995. Cell Growth Differentiation6, 1063.
Chen, C., et al. 1994. Science266, 291.
Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun.195, 608.
Niki, I., et al. 1993. Biochem. Biophys. Res. Commun.191, 255.
Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun.181, 968.
Tokumitsu, H., et al. 1990. J. Biol. Chem.265, 4315.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

188.6 °F - closed cup - (Dimethylsulfoxide)

Flash Point(C)

87 °C - closed cup - (Dimethylsulfoxide)

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 3 petroleums
Hazardous rank III
Water insoluble liquid

JAN Code

422712-1MG:

Certificates of Analysis (COA)

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