420413

Polymyxin B Sulfate, Sterile-Filtered Aqueous Solution, Cell Culture Tested

An antibiotic that inhibits phospholipid sensitive Ca2+-dependent protein kinase.

• Synonym(s): Polymyxin B Sulfate, Sterile-Filtered Aqueous Solution, Cell Culture Tested, Aerosporin, Sterile-Filtered Aqueous Solution, Cell Culture Tested
• CAS Number: 1405-20-5
• MDL number: MFCD00131991
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: clear
• shipped in: wet ice
• storage temp.: −20°C
• InChI: 1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
• InChI key: HNDFYNOVSOOGDU-UHFFFAOYSA-N

Description

General description

An antibiotic that inhibits phospholipid sensitive Ca²⁺-dependent protein kinase. Mixture of polymyxin B₁ sulfate and polymyxin B₂ sulfate. Binds to cell wall and makes it more permeable, causing fluid uptake. Effective against Gram-negative bacteria.

Biochem/physiol Actions

≥7500 units/mg

Warning

Toxicity: Harmful (C)

Physical form

Supplied at 50 mg/ml in H₂O.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Lucas, M., et al. 1994. Biochem. Pharmacol.47, 667.
Ngezahayo, A. and Kolb, H.A. 1993. Pflugers Arch.422, 413.
Kubo, M. and Okada, Y. 1992. J. Physiol.456, 351.
Strasser, R.H., et al. 1992. Circ. Res.70, 1304.
Hegemann, L., et al. 1991. Eur. J. Pharmacol.207, 17.
Inaba, H. and Finkins, J.P. 1991. Am. J. Physiol.261, R26.
Marra, M.N., et al. 1990. J. Immunol.144, 662.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable