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Safety Information

420134

Sigma-Aldrich

JNK Inhibitor VII, TAT-TI-JIP153-163, Cell-Permeable

The JNK Inhibitor VII, TAT-TI-JIP153-163, Cell-Permeable controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

JNK Inhibitor VII, TAT-TI-JIP153-163, Cell-Permeable, H₂N-YGRKKRRQRRR-RPKRPTTLNLF-NH₂, TAT₃₈₋₄₈ -Truncated Inhibitor based on JNK-Interacting Protein 1

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About This Item

Empirical Formula (Hill Notation):
C125H220N52O27
Molecular Weight:
2883.42
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥97% (HPLC)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

solubility

water: 1 mg/mL
DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

The non-permeant JNK inhibitor peptide TI-JIP153-163 (Cat. No. 420133) is made cell-permeable with an N-terminal TAT protein transduction domain sequence. Shown to offer neuroprotection in a rat ischemic brain injury model in in vivo.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
JNK
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH₂

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Guan, Q.H., et al. 2006. Neuroscience, 139, 609.
Barr, R.K., et al. 2004. J. Biol. Chem.279, 36327.
Bogoyevitch, M.A., et al. 2003. Cell. Mol. Biol. Lett.8, 550.
Barr, R.K., et al. 2002. J. Biol. Chem.277, 10987.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

420134-2MG:
420134-MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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