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Safety Information

238900

Sigma-Aldrich

4-Cyano-3-methylisoquinoline

A potent, cell-permeable, reversible, and specific inhibitor of protein kinase A (IC₅₀ = 30 nM).

Synonym(s):

4-Cyano-3-methylisoquinoline, PKA Inhibitor XI

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About This Item

Empirical Formula (Hill Notation):
C11H8N2
CAS Number:
161468-32-2
Molecular Weight:
168.19
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C11H8N2/c1-8-11(6-12)10-5-3-2-4-9(10)7-13-8/h2-5,7H,1H3

InChI key

SZWLGBJCLZDZBY-UHFFFAOYSA-N

General description

A potent, cell-permeable, reversible, and specific inhibitor of protein kinase A (IC50 = 30 nM). Inhibition is competitive with respect to ATP. Shows only weak inhibitory activities against Ca2+-dependent protein kinase (CDPK), MLCK, PKC, and cyclic nucleotide-binding phosphatase.
A potent, cell-permeable, specific inhibitor of protein kinase A (PKA; IC50 = 30 nM). Inhibition is competitive with respect to ATP. Shows only weak inhibitory activities against Ca2+-dependent protein kinase (CDPK), MLCK, PKC, and cyclic nucleotide-binding phosphatase (Pase).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
PKA
Product competes with ATP.
Reversible: yes
Target IC50: 30 nM against protein kinase A

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Lu, Z.X., et al. 1996. Biol. Chem. Hoppe Seyler 377, 373.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Deleterious substance

JAN Code

238900-5MG:
238900-VMG:
238900-MG:
238900-1.1ML:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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