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Key Documents

Safety Information

234403

Sigma-Aldrich

Complement C3-Depleted Serum, Human

Synonym(s):

Complement serum, Human serum

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.25

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

color

clear yellow

shipped in

dry ice

storage temp.

−70°C

General description

Complement C3-depleted serum is a human serum that is depleted of complement component C3. It is prepared from serum that has been shown by certified tests to be negative for Hepatitis B surface antigen (HBsAg) and antibodies to hepatitis C virus (HCV), human immunodeficiency virus (HIV-I), and HIV-II.

Application

Complement C3-Depleted Serum, Human has been used to study its effects on the α-secretase activity of umbilical cord blood serum (CBS).

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Standard Handling (A)

Unit Definition

Classical Pathway Activity: One C3H50 unit measured by classical pathway activation is defined as the amount of C3 required to yield 50% lysis of 3 x 10⁷ EA when incubated in the presence of the recommended volume of C3-Dpl for 30 min at 37°C in a total reaction volume of 500 µl GVB++.

Physical form

In 150 mM NaCl, 50 mM sodium phosphate, pH 7.2.

Preparation Note

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HCV, HIV-I, and HIV-II.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

234403-ML:
234403-1ML:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ahsan Habib et al.
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Alzheimer's Disease (AD) is the leading cause of dementia in the elderly. In healthy individuals, amyloid precursor protein (APP) is cleaved by α-secretase, generating soluble α-amyloid precursor protein (sAPPα), which contributes neuroprotective functions in the neuronal environment. In contrast, in

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