230752

Chromomycin A₃

Antitumor antibiotic that inhibits RNA synthesis. A cell-permeable fluorescent dye that can be used with Bisbenzimide H 33258 to distinguish chromosomes by their total DNA content and DNA base composition.

• Synonym(s): Chromomycin A₃, Toyomycin
• Empirical Formula (Hill Notation): C₅₇H₈₂O₂₆
• CAS Number: 7059-24-7
• Molecular Weight: 1183.25
• MDL number: MFCD00043151
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥90% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: yellow
• solubility: ethanol: 10 mg/mL
• fluorescence: λ_ex ~445 nm; λ_em ~575 nm
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C57H82O26/c1-21-34(79-40-19-37(53(26(6)75-40)77-28(8)59)82-38-16-33(61)52(70-11)25(5)74-38)15-31-13-30-14-32(54(71-12)51(68)46(63)22(2)58)55(50(67)44(30)49(66)43(31)45(21)62)83-41-18-35(47(64)24(4)73-41)80-39-17-36(48(65)23(3)72-39)81-42-20-57(10,69)56(27(7)76-42)78-29(9)60/h13,15,22-27,32-33,35-42,46-48,52-56,58,61-66,69H,14,16-20H2,1-12H3/t22-,23-,24-,25-,26-,27+,32+,33-,35-,36-,37-,38-,39+,40+,41+,42+,46+,47-,48-,52+,53+,54+,55+,56+,57+/m1/s1
• InChI key: ZYVSOIYQKUDENJ-WKSBCEQHSA-N

Description

General description

Antibiotic that inhibits RNA synthesis by way of DNA-dependent RNA polymerase. Fluorescent dye that can be used in conjunction with Bisbenzimide H33258 (Cat. No. 382061) to distinguish chromosomes by their total DNA concentration and their DNA base composition. Binds to G:C pairs of helical DNA (Mg²⁺ required) but does not intercalate the A:T pairs, which preferentially bind Bisbenzimide H33258.

Antitumor antibiotic that inhibits RNA synthesis. A cell-permeable fluorescent dye that can be used with Bisbenzimide H 33258 (Cat. No. 382061) to distinguish chromosomes by their total DNA content and DNA base composition. Reversibly interacts with DNA in the presence of Mg²⁺. Binds to G:C pairs of helical DNA but does not intercalate.

Warning

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

Reconstitution

Following recosntitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Aich, P., et al. 1992. Biochemistry31, 2988.
Saccone, S., et al. 1992. Proc. Natl. Acad. Sci. USA89, 4913.
Van Dilla, M.A., et al. 1983. Science220, 620.
Mizuno, K. 1963. J. Antibiot.16, 22.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H300
• Precautionary Statements: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 1 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable