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Safety Information

178251

Sigma-Aldrich

α1-Antitrypsin, Human Plasma

α₁-Antitrypsin, CAS 9041-92-3, is a protease inhibitor of the serpin superfamily. Inhibits elastase, cathepsin G, and proteinase 3.

Synonym(s):

α1-Antitrypsin, Human Plasma, α₁-AT, α₁-Proteinase Inhibitor, 3.5S α₁-Glycoprotein

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About This Item

CAS Number:
9041-92-3
MDL number:
MFCD00130469
UNSPSC Code:
12352202
NACRES:
NA.77

Quality Level

100

Assay

≥95% (SDS-PAGE)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

water: soluble

shipped in

ambient

storage temp.

−20°C

General description

A single polypeptide chain of 394 amino acids and three carbohydrate side chains linked to asparagine residues present at about 290 mg/100 ml in acute phase plasma. Serine protease inhibitor that also acts as a major physiological regulator of elastase. Inhibitor of neutrophil elastase, cathepsin G, and proteinase 3.
A single polypeptide chain of 394 amino acids and three carbohydrate side chains linked to asparagine residues. Present at about 290 mg/100 ml in acute phase plasma. Serine protease inhibitor that also acts as a major physiological regulator of elastase.

Biochem/physiol Actions

Cell permeable: no
Primary Target
serine proteases
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Physical form

Lyophilized from 300 mM NaCl, 30 mM sodium phosphate buffer, pH 6.5.

Preparation Note

Please refer to vial label for lot-specific volume prior to lyophilization.
Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.

Analysis Note

>=75% inhibition with active-site titrated porcine trypsin using benzoyl-Arg-p-nitroanilide (Bz-Arg-pNA) as the substrate.

Other Notes

Coakley, R.J., et al. 2001. Am. J. Med. Sci.321, 33.
Travis, J., and Salvesen, G.S. 1983. Annu. Rev. Biochem.52, 655.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

178251-5RMG:
178251-5MG:
178251-1RMG:
178251-100MG:
178251-1MG:
178251-0MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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