17-493

PI3 Kinase Activity/Inhibitor ELISA

• UNSPSC Code: 12161503
• eCl@ss: 32161000
• NACRES: NA.28

Properties

• description: analytes available: PI 3-Kinase
• Quality Level: 100
• technique(s): activity assay: suitable
• UniProt accession no.: P42336
• detection method: colorimetric; fluorometric

Description

General description

FUNCTION: SwissProt: P42336 # Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.
SIZE: 1068 amino acids; 124284 Da
SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Binds to IRS1 in nuclear extracts. Interacts with RUFY3 (By similarity).
DISEASE: SwissProt: P42336 # Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500]. & Defects in PIK3CA are associated with breast cancer [MIM:114480]. & Defects in PIK3CA are associated with epithelial ovarian cancer (EOC) [MIM:604370].
SIMILARITY: SwissProt: P42336 ## Belongs to the PI3/PI4-kinase family. & Contains 1 C2 domain. & Contains 1 PI3K/PI4K domain.

Packaging

Kit capacity: 96 wells

Components

Glutathione-Coated Plate, 96-well strip format 20% TWEEN^® 20 20X TBS Wash Substrate TMB Stop Buffer SA-HRP Detection Reagent GRP1-GST Kinase Reaction Buffer, 5X Wortmannin PIP2 Biotinylated-PIP3 PI3K, p110α PI3K, p110β PI3K, p110δ PI3K, p120γ

Legal Information

TWEEN is a registered trademark of Croda International PLC

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Pictograms: GHS06,GHS05
• Signal Word: Danger
• Hazard Statements: H290,H300 + H310 + H330,H317
• Precautionary Statements: P234 - P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 1 Inhalation - Acute Tox. 1 Oral - Acute Tox. 2 Dermal - Met. Corr. 1 - Skin Sens. 1
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3