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Key Documents

Safety Information

14-378

Sigma-Aldrich

MKK4/SKK1 Protein, inactive, 50 g

Unactive, recombinant mouse MKK4, corresponding to amino acids 35-397, fused to an N-terminal GST-tag, for use in Kinase Assays.

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About This Item

UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.32

biological source

mouse

Quality Level

100

recombinant

expressed in E. coli

mol wt

Mw 65 kDa

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

NCBI accession no.

NM_003010.2

UniProt accession no.

P45985

shipped in

dry ice

Gene Information

mouse ... MAP2K4(26398)

General description

Product Source: expressed in E. coli
Recombinant mouse MKK4, corresponding to amino acids 35-397, fused to an Nterminal GST-tag

Biochem/physiol Actions

Protein Target: MKK4
Target Sub-Family: STE

Quality

routinely evaluated by phosphorylation of ATF2 substrate

Physical form

GSH-agarose chromatography

Storage and Stability

6 months at -20C

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317

Hazard Classifications

Skin Sens. 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Deleterious substance

JAN Code

14-378:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Eleanore A Gross et al.
The Journal of biological chemistry, 277(16), 13873-13882 (2002-02-12)
Mitogen-activated protein (MAP) kinase pathways are three-kinase modules that mediate diverse cellular processes and have been highly conserved among eukaryotes. By using a functional complementation screen in yeast, we have identified a human MAP kinase kinase kinase (MAPKKK) that shares
Luis Cedeno-Rosario et al.
The Journal of biological chemistry, 298(8), 102263-102263 (2022-07-18)
Mixed lineage kinase 3 (MLK3) is a serine/threonine mitogen-activated protein kinase kinase kinase that promotes the activation of multiple mitogen-activated protein kinase pathways and is required for invasion and proliferation of ovarian cancer cells. Inhibition of MLK activity causes G2/M

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