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Safety Information

1.08386

SAFC

Tris(hydroxymethyl)aminomethane

(Trometamol), EMPROVE® EXPERT, Ph. Eur., BP, ChP, JPC, USP

Pharma Manufacturing

Synonym(s):

Tromethamine, 2-Amino-2-(hydroxymethyl)-1,3-propanediol, THAM, Tris base, Trometamol

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About This Item

Linear Formula:
NH2C(CH2OH)3
CAS Number:
77-86-1
Molecular Weight:
121.14
Beilstein:
741883
MDL number:
MFCD00004679
UNSPSC Code:
12352104
EC Index Number:
201-064-4

Agency

BP
ChP
JPC
Ph. Eur.
USP

Quality Level

500

vapor pressure

0.0267 hPa ( 20 °C)

product line

EMPROVE® EXPERT

form

solid

pH

10.2-10.6 (20 °C, 6 g/L in H2O)

useful pH range

7-9

pKa (25 °C)

8.1

bp

219-220 °C/10 mmHg (lit.)
219-220 °C/13.3 hPa

mp

167-172 °C (lit.)

solubility

678 g/L

density

1.35 g/cm3 at 23 °C

application(s)

ophthalmics
pharmaceutical

storage temp.

no temp limit

SMILES string

NC(CO)(CO)CO

InChI

1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2

InChI key

LENZDBCJOHFCAS-UHFFFAOYSA-N

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Tris(hydroxymethyl)aminomethane (Trometamol) is a commonly used buffer component in biomolecule downstream chromatography steps as well as final liquid formulation.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Application

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Description
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Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

1083860000:
2328386:
1083865000:
1083865000BWT:
1083860003:
1083864010:
1083869999:
1083869336:
1.08386.5000DISC:
1083864025:
1083864100:
1083869025:
1083868888:
1083861000BWT:
1083869500:
1083869026:
CO1E1083861000:
1083860403:
1083869025BWT:
1083863010:
1083860050:
1083869027:
1083869013:
1083861000:
1083869024:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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