Merck
All Photos(3)

8.17061

SAFC

TWEEN® 80 (Polysorbate)

EMPROVE® ESSENTIAL, Ph. Eur., JP, NF

All Photos(3)
Synonym(s):
Polysorbate 80, POE (20) sorbitan monooleate, Polyethylene glycol sorbitan monooleate, Polyoxyethylenesorbitan monooleate
CAS Number:
9005-65-6
MDL number:
MFCD00082107
EC Index Number:
500-019-9

Agency

JP
NF
Ph. Eur.

Quality Level

500

vapor pressure

<1.33 hPa

product line

EMPROVE® ESSENTIAL

form

viscous liquid

technique(s)

API processing | nano-milling: suitable

pH

5-7 (20 °C, 50 g/L in H2O)

kinematic viscosity

300-500 cSt(25 °C)

bp

>100 °C/1013 hPa

transition temp

flash point >149 °C

density

1.07 g/cm3 at 25 °C

application(s)

liquid formulation
ophthalmics
pharma/biopharma processes
pharmaceutical
semi-solid formulation
solid formulation
solubility enhancement

storage temp.

15-25°C

InChI

1S/C32H60O10/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-30(36)40-25-24-37-27-29(39-22-19-34)32-28(38-21-18-33)26-31(42-32)41-23-20-35/h9-10,28-29,31-35H,2-8,11-27H2,1H3/b10-9+

InChI key

RGPBUVUVZKQNHD-MDZDMXLPSA-N

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This Item
PHR379059924655207
TWEEN&#174; 80 (Polysorbate) EMPROVE&#174; ESSENTIAL, Ph. Eur., JP, NF

SAFC

8.17061

TWEEN® 80 (Polysorbate)

Polysorbate 80 certified reference material, pharmaceutical secondary standard

Supelco

PHR3790

Polysorbate 80

Polysorbate 80 tested according to Ph. Eur.

Sigma-Aldrich

59924

Polysorbate 80

TWEEN&#174; 80 PROTEIN GRADE Detergent, 10% Solution, Sterile-Filtered. Non-ionic detergent used for immunoprecipitation and for the solubilization of membrane-bound proteins. Supplied as a 10% (W/W) solution of PROTEIN GRADE TWEEN 80 detergent. Conductivity:&#8804;50 &#181;mhos.

Millipore

655207

TWEEN® 80

product line

EMPROVE® ESSENTIAL

product line

-

product line

-

product line

-

form

viscous liquid

form

-

form

liquid

form

liquid

technique(s)

API processing | nano-milling: suitable

technique(s)

-

technique(s)

-

technique(s)

-

transition temp

flash point >149 °C

transition temp

-

transition temp

cloud point 65 °C

transition temp

-

density

1.07 g/cm3 at 25 °C

density

-

density

1.064 g/mL at 25 °C (lit.)

density

-

application(s)

liquid formulation
ophthalmics
pharma/biopharma processes
pharmaceutical
semi-solid formulation
solid formulation
solubility enhancement

application(s)

pharmaceutical

application(s)

pharmaceutical (small molecule)

application(s)

-

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Polysorbate 80 is used as surfactant in a variety of liquid formulations and acts e.g. as emulsifying, solubilizing and wetting agent.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
TWEEN is a registered trademark of Croda International PLC

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

> 113 °C - closed cup

What is the Emprove® Program?

The Emprove® Program is a system providing comprehensive and thorough documentation of our filters and single-use components, pharma raw materials, and starting materials. Four document types are included with an Emprove® Program subscription:

Material Qualification Dossier

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Quality Management Dossier

Available by subscription or for a fee

Operational Excellence Dossier

Available by subscription or for a fee

Learn more about the benefits an Emprove® Program subscription can provide
Why are these documents unavailable?
Emprove® Dossiers contain information intended to support the registration process and risk assessment activities of pharmaceutical producers and contain confidential information. Please contact us if you would like access.

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