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Key Documents

Safety Information

N-913

Supelco

(+)-Norpropoxyphene maleate solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C25H31NO6
CAS Number:
Molecular Weight:
441.52
EC Number:
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

2-8°C

SMILES string

OC(=O)\C=C/C(O)=O.CCC(=O)O[C@@](Cc1ccccc1)([C@H](C)CNC)c2ccccc2

InChI

1S/C21H27NO2.C4H4O4/c1-4-20(23)24-21(17(2)16-22-3,19-13-9-6-10-14-19)15-18-11-7-5-8-12-18;5-3(6)1-2-4(7)8/h5-14,17,22H,4,15-16H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t17-,21+;/m1./s1

InChI key

HCQPFYNZJNOOKN-YKNFWSLESA-N

General description

Norpropoxyphene is a major urinary metabolite of the opioid analgesic drug propoxyphene. Norpropoxyphene′s toxicity makes the parent drug more likely to cause death from overdose compared to similar mild opioid analgesics. This analytical reference standard is suitable for use as a starting material in the preparation of calibrators or controls for LC/MS or GC/MS testing methods in clinical toxicology, urine drug testing, forensic analysis or pain prescription monitoring.

Application


  • Forensic toxicology: (+)-Norpropoxyphene maleate is utilized in liquid chromatography-high-resolution mass spectrometry for the quantification of opioids and their derivatives in whole blood, demonstrating its application in forensic cases to analyze the involvement of these substances in fatal incidents (Feliu et al., 2020).

  • Pharmacokinetic analysis: This compound plays a crucial role in the simultaneous quantitation of multiple opioids in human plasma, utilizing solid-phase extraction and gas chromatography/mass spectrometry. This method is validated for its application in assessing the cardiovascular safety of therapeutic doses, underlining its importance in clinical pharmacology (Fernández et al., 2017).

  • Drug metabolism in maternal health: (+)-Norpropoxyphene maleate is used in studies focusing on the liquid chromatographic determination of propoxyphene and its metabolites in plasma and breast milk, offering insights into drug safety and metabolism in maternal health contexts (Kunka et al., 1985).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Alcohols
Hazardous rank II

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

N-913-1ML:4548173341132
N-913-CC:


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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