M-194

(±)-cis-3-Methylfentanyl hydrochloride solution

100 μg/mL in methanol (as free base), certified reference material, ampule of 0.5 mL, Cerilliant^®

• Empirical Formula (Hill Notation): C₂₃H₃₀N₂O · HCl
• CAS Number: 78995-18-3
• Molecular Weight: 386.96
• MDL number: MFCD25974419
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material
• Quality Level: 300
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 0.5 mL
• manufacturer/tradename: Cerilliant^®
• drug control: estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
• concentration: 100 μg/mL in methanol (as free base)
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): forensics and toxicology
• format: single component solution
• storage temp.: −20°C
• InChI: 1S/C23H30N2O.ClH/c1-3-23(26)25(21-12-8-5-9-13-21)22-15-17-24(18-19(22)2)16-14-20-10-6-4-7-11-20;/h4-13,19,22H,3,14-18H2,1-2H3;1H/t19-,22+;/m0./s1
• InChI key: GQIWDGKLQJBQJU-MGBOEYOKSA-N

Description

General description

A designer drug and fentanyl analog, (±)-cis-3-Methylfentanyl has an estimated potency 400 to 6000 times greater than morphine. This Certified Spiking Solution^® is suitable for use as starting material in calibrators and controls for (±)-cis-3-Methylfentanyl LC/MS or GC/MS testing methods in clinical toxicology, urine drug testing, prescription monitoring, or forensic analysis applications.

Application

• HPLC-UV and GC-MS Methods for Determination of Chlorambucil and Valproic Acid in Plasma for Further Exploring a New Combined Therapy of Chronic Lymphocytic Leukemia.: This study employed the LiChrospher^® 100 RP-18 endcapped (5µm) Hibar^® RT 125-2 column for high-performance liquid chromatography analysis of chlorambucil and valproic acid in plasma. The method facilitated efficient separation and detection, critical for evaluating combined chemotherapy protocols (Lipska K et al., 2021).


• Application of chemometric approach for development and validation of high performance liquid chromatography method for estimation of ropinirole hydrochloride.: This research utilized the LiChrospher^® 100 RP-18 endcapped (5µm) Hibar^® RT 125-2 column to develop and validate a robust HPLC method for the quantification of ropinirole hydrochloride. The study demonstrated the column′s capability in achieving high sensitivity and precision in pharmaceutical analysis (Fatima S et al., 2019).


• Determination of retinol and retinyl esters in human plasma by high-performance liquid chromatography with automated column switching and ultraviolet detection.: The LiChrospher^® 100 RP-18 endcapped (5µm) Hibar^® RT 125-2 column was applied in the analysis of retinol and its esters in human plasma. This study showcased the column′s efficiency in separating closely related compounds, essential for accurate biochemical assays (Hartmann S et al., 2001).


• Rapid, highly sensitive method for the determination of morphine and its metabolites in body fluids by liquid chromatography-mass spectrometry.: This investigation leveraged the LiChrospher^® 100 RP-18 endcapped (5µm) Hibar^® RT 125-2 column to develop a sensitive LC-MS method for morphine and its metabolites. The column′s performance ensured reliable detection in forensic and clinical toxicology (Schänzle G et al., 1999).


• Determination of 13-cis-3-hydroxyretinoic acid, all-trans-3-hydroxyretinoic acid and their 4-oxo metabolites in human and animal plasma by high-performance liquid chromatography with automated column switching and UV detection.: This study used the LiChrospher^® 100 RP-18 endcapped (5µm) Hibar^® RT 125-2 column for the simultaneous analysis of retinoic acid metabolites, highlighting its application in pharmacokinetics and metabolism research (Wyss R et al., 1998).


• Determination of endogenous levels of 13-cis-retinoic acid (isotretinoin), all-trans-retinoic acid (tretinoin) and their 4-oxo metabolites in human and animal plasma by high-performance liquid chromatography with automated column switching and ultraviolet detection.: The research focused on using the LiChrospher^® 100 RP-18 endcapped (5µm) Hibar^® RT 125-2 column for analyzing endogenous retinoic acids in plasma, demonstrating the column′s utility in clinical biochemistry and toxicology studies (Wyss R et al., 1997).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Hibar is a registered trademark of Merck KGaA, Darmstadt, Germany

LiChrospher is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225,H301 + H311 + H331,H370
• Precautionary Statements: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Target Organs: Eyes
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 49.5 °F - closed cup
• Flash Point(C): 9.7 °C - closed cup