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Safety Information

A-150

Supelco

Aprobarbital solution

1 mg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C10H14N2O3
CAS Number:
Molecular Weight:
210.23
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

Quality Level

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

SMILES string

O=C1C(C(C)C)(CC=C)C(NC(N1)=O)=O

InChI

1S/C10H14N2O3/c1-4-5-10(6(2)3)7(13)11-9(15)12-8(10)14/h4,6H,1,5H2,2-3H3,(H2,11,12,13,14,15)

InChI key

UORJNBVJVRLXMQ-UHFFFAOYSA-N

General description

Aprobarbital, also known as aprobarbitone, is sold as Oramon, Somnifaine and Allonal. Aprobarbital has sedative, hypnotic and anticonvulsant properties and was primarily used for the treatment of insomnia. This Snap-N-Spike Reference Solution is applicable for use in applications including clinical toxicology, medication monitoring, urine drug testing, and forensic analysis by LC-MS/MS or GC/MS.

Application


  • Rapid quantification of phenobarbital and barbital in human whole blood by liquid-liquid extraction combined with DART-orbitrap-HRMS: This method showcases the use of Aprobarbital-related compounds for forensic toxicology, highlighting its potential in precise legal and clinical diagnostics (Ke et al., 2023).

  • Quantitative Determination of Methohexital in Human Whole Blood by Liquid Chromatography Tandem Mass Spectrometry: The study emphasizes the critical role of barbiturates like Aprobarbital in therapeutic monitoring, contributing to safer and more effective drug administration protocols (Zhang et al., 2021).

  • Occurrence and fate of barbiturates in the aquatic environment: Research into environmental toxicology of compounds including Aprobarbital, providing insights into pollution control and drug lifecycle analysis (Peschka et al., 2006).

  • Determinations of zidovudine/didanosine/nevirapine and zidovudine/didanosine/ritonavir in human serum by micellar electrokinetic chromatography: This analytical technique underlines the broader utility of methodologies applicable to barbiturate analysis like Aprobarbital in complex biological matrices (Fan and Stewart, 2002).

  • Determination of lamivudine/stavudine/efavirenz in human serum using liquid chromatography/electrospray tandem mass spectrometry with ionization polarity switch: Demonstrates advanced analytical capabilities potentially extendable to Aprobarbital, enhancing drug monitoring and pharmacokinetic studies (Fan et al., 2002).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Alcohols
Hazardous rank II

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

A-150-1ML:


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Protocols

HPLC Analysis of Barbiturates in Serum on Discovery® C18 after SPE using Discovery® DSC-18Lt

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