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880126C

Avanti

DSPE-PEG(2000) Maleimide

Avanti Polar Lipids 880126C

Synonym(s):

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000] (ammonium salt)

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About This Item

CAS Number:
474922-22-0
UNSPSC Code:
12352211
NACRES:
NA.25

form

liquid

packaging

pkg of 1 × 2 mL (880126C-50mg)
pkg of 1 × 2.5 mL (880126C-25mg)
pkg of 1 × 4 mL (880126C-100mg)

manufacturer/tradename

Avanti Polar Lipids 880126C

concentration

10 mg/mL (880126C-25mg)
25 mg/mL (880126C-100mg)
25 mg/mL (880126C-50mg)

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCCNC(OCCOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO/C=C\NC(CCN(C(C=C1)=O)C1=O)=O)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C=C.C

General description

DSPE-PEG(2000) Maleimide is a functionalized PEG Lipid conjugate.

Application

DSPE-PEG(2000) Maleimide has been used:
  • in the preparation of neutral liposome
  • in the preparation of immunoliposomes
  • to conjugate with P5 peptide to improve peptide incorporation into liposomes

Biochem/physiol Actions

Maleimide are useful in biomolecular conjugation.

Packaging

5 mL Clear Glass Sealed Ampule (880126C-100mg)
5 mL Clear Glass Sealed Ampule (880126C-25mg)
5 mL Clear Glass Sealed Ampule (880126C-50mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

880126C-25MG:4.548173358758E12
880126C-50MG:4.548173358765E12
880126C-100MG:4.548173358741E12

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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MPL nano-liposomal vaccine containing P5 HER2/neu-derived peptide pulsed PADRE as an effective vaccine in a mice TUBO model of breast cancer
Zamani P, et al.
J. Controlled Release, 303, 223-236 (2019)
Catalysis of imido-group hydrolysis in a maleimide conjugate
Kalia J and Raines RT
Bioorganic & Medicinal Chemistry Letters, 17, 6286?6289-6286?6289 (2007)
Araz Norouz Dizaji et al.
Journal of biomaterials science. Polymer edition, 31(3), 293-309 (2019-11-26)
This study aims to develop fluorescence labelled polymeric nanoparticle (NP) carrying vancomycin as the targeting agent for in vivo imaging of Methicillin-resistant Staphylococcus aureus bacterial infections in animal models. Maleimide functionalized 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide (polyethylene glycol)-2000] as the main was carrier matrix to
Yen Ling Yeow et al.
EMBO molecular medicine, 11(12), e10923-e10923 (2019-11-12)
High extracellular matrix (ECM) content in solid cancers impairs tumour perfusion and thus access of imaging and therapeutic agents. We have devised a new approach to degrade tumour ECM, which improves uptake of circulating compounds. We target the immune-modulating cytokine
In vitro comparison of liposomal drug delivery systems targeting the oxytocin receptor: a potential novel treatment for obstetric complications
Hua S and Vaughan B
International journal of nanomedicine, 14, 2191-2191 (2019)
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