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Safety Information

850365C

Avanti

18:0 PC (DSPC)

Avanti Research - A Croda Brand

Synonym(s):

1,2-dioctadecanoyl-sn-glycero-3-phosphocholine; DSPC; PC(18:0/18:0)

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About This Item

Empirical Formula (Hill Notation):
C44H88NO8P
CAS Number:
Molecular Weight:
790.15
UNSPSC Code:
51191904
NACRES:
NA.25

description

1,2-distearoyl-sn-glycero-3-phosphocholine, chloroform

Assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (850365C-25mg)
pkg of 1 × 20 mL (850365C-500mg)
pkg of 2 × 20 mL (850365C-1g)
pkg of 2 × 4 mL (850365C-200mg)

manufacturer/tradename

Avanti Research - A Croda Brand

concentration

10 mg/mL (850365C-25mg)
25 mg/mL (850365C-1g)
25 mg/mL (850365C-200mg)
25 mg/mL (850365C-500mg)

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

InChI

1S/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3/t42-/m1/s1

InChI key

NRJAVPSFFCBXDT-HUESYALOSA-N

General description

The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Application

18:0 PC (DSPC) has been used in the preparation of microbubbles (MBs). It is suitable for use in the synthesis of methylene blue (MB)-liposome synthesis and in the preparation of unilamellar vesicles

Biochem/physiol Actions

18:0 PC (DSPC) liposomes/1,2-Dioctadecanoyl-sn-glycero-3-phosphocholine, along with Rhamnolipids (RLs) can serve as the best combination for drug delivery application. It can help to maintain the stability of curcumin.

Packaging

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (850365C-1g)
30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (850365C-500mg)
5 mL Clear Glass Sealed Ampule (850365C-200mg)
5 mL Clear Glass Sealed Ampule (850365C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

also commonly purchased with this product

Product No.
Description
Pricing

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Target Organs

Central nervous system, Liver,Kidney

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PRTR

Class I Designated Chemical Substances

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

850365C-1G:4548174018217
850365C-500MG:4548174018200
850365C-VAR:
850365C-200MG:4548174018224
850365C-25MG:4548174018194
850365C-BULK:


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Interaction of curcumin with 1, 2-dioctadecanoyl-sn-glycero-3-phosphocholine liposomes: Intercalation of rhamnolipids enhances membrane fluidity, permeability and stability of drug molecule
Moussa Z, et al.
Colloids and Surfaces. B, Biointerfaces, 149, 30-37 (2017)
Methylene-Blue-Encapsulated Liposomes as Photodynamic Therapy Nano Agents for Breast Cancer Cells
Wu PT, et al.
Nanomaterials, 9(1), 14-14 (2019)
Ana Reis et al.
Biochimica et biophysica acta. Biomembranes, 1862(2), 183133-183133 (2019-12-01)
Food polyphenols in fruits juices, tea, coffee, wine and beer confer sensory properties such as colour, astringency and bitterness. The development of functional healthy drinks without the unpleasant sensory feeling is boosting research for a clearer understanding on the interactions
Tadaharu Suga et al.
Molecular pharmaceutics, 15(10), 4481-4490 (2018-09-05)
High-functionality and -quality (HFQ) lipids have a discrete molecular weight and good water dispersibility and can be produced by solid-phase peptide synthesis. Therefore, HFQ lipids are a promising material for the preparation of ligand-grafted PEGylated liposomes. Recently, we have reported
Liposome layers characterized by quartz crystal microbalance measurements and multirelease delivery
Brochu H and Vermette P
Langmuir, 23(14), 7679-7686 (2007)

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