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Safety Information

P9906

Sigma-Aldrich

Poly(ethylene glycol) bis(amine)

average MN 3,400, cross-linking reagent carboxyl reactive, amine

Synonym(s):

Polyethylene glycol, O,O′-Bis(2-aminoethyl)polyethylene glycol, Diaminopolyethylene glycol, PEG-diamine, Polyoxyethylene bis(amine)

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About This Item

Linear Formula:
H2N(CH2CH2O)nCH2CH2NH2
CAS Number:
MDL number:
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.23

product name

Poly(ethylene glycol) bis(amine), average Mn 3400

form

powder

mol wt

average Mn 3400

reaction suitability

reagent type: cross-linking reagent
reactivity: carboxyl reactive

Ω-end

amine

α-end

amine

polymer architecture

shape: linear
functionality: homobifunctional

storage temp.

2-8°C

InChI

1S/C6H16N2O2/c7-1-3-9-5-6-10-4-2-8/h1-8H2

InChI key

IWBOPFCKHIJFMS-UHFFFAOYSA-N

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Application

Poly(ethylene glycol) bis(amine) may be used in the preparation of folic acid-PEG-NH2 conjugate. PEG-bis(amine) has been reported to be used as a component in the making of Au-Fe2O3 NPs based multifunctional nanoprobe for multimodal and ultrasensitive detection of cancer cells.

Preparation Note

Prepared from PEG with an average molecular weight of 3,350

Pictograms

Health hazardCorrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Dam. 1 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PRTR

Class I Designated Chemical Substances

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

P9906-BULK:
P9906-1G:4548174006153
P9906-5G:4548174006160
P9906-VAR:


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Development and characterization of folate targeted nanoparticle drug delivery system
mittal V, et al.
International Journal of Pharmacy and Biological Sciences, V1(2) (2010)
Jian Liu et al.
Chemical communications (Cambridge, England), 49(43), 4938-4940 (2013-04-23)
A multifunctional nanoprobe, which can be used for dual modal imaging and the detection of cancer cells, has been reported.
Evaluation of receptor mediated endocytosis on cellular internalization: a comparative study of pegylated nanoparticles and folate anchored pegylated nanoparticles on mda-mb-231 cells
Mahalwar A, et al.,
International Journal of Biological & Pharmaceutical Research null
Development and characterization of folate targeted nanoparticle drug delivery system
Mittal V, et al.
International Journal of Pharmacy and Biological Sciences, V1(2) (2000)
Takahiko Matsushita et al.
The Journal of organic chemistry, 71(8), 3051-3063 (2006-04-08)
A MUC1-related glycopeptide having five core-2 hexasaccharide branches (C330H527N46O207, MW = 8450.9) was synthesized by a new strategy using a combination of microwave-assisted solid-phase synthesis (MA-SPGS) and enzymatic sugar elongation. Synthesis of a key glycopeptide intermediate was best achieved in

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