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753084

Sigma-Aldrich

Poly(ethylene glycol) diamine

average MN 2,000, cross-linking reagent carboxyl reactive, amine

Synonym(s):

Poly(ethylene glycol) bis(amine), Polyethylene glycol, O,O′-Bis(2-aminoethyl)polyethylene glycol, Diaminopolyethylene glycol, PEG-diamine, Polyoxyethylene bis(amine)

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About This Item

Linear Formula:
H2N(CH2CH2O)nCH2CH2NH2
CAS Number:
24991-53-5
MDL number:
MFCD00132004
UNSPSC Code:
12162002
NACRES:
NA.23

Product Name

Poly(ethylene glycol) diamine, average Mn 2,000

form

powder

mol wt

Mw/Mn ≤1.4
average Mn 2,000

reaction suitability

reagent type: cross-linking reagent
reactivity: carboxyl reactive

Ω-end

amine

α-end

amine

polymer architecture

shape: linear
functionality: homobifunctional

SMILES string

NCCOCCOCCN

InChI

1S/C6H16N2O2/c7-1-3-9-5-6-10-4-2-8/h1-8H2

InChI key

IWBOPFCKHIJFMS-UHFFFAOYSA-N

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General description

Poly(ethylene glycol) diamine (PEGD) is a non-toxic biopolymer which has properties such as biocompatibility and biodegradability. It can be reacted with crosslinking agents to form a three dimensional mesh that can be used in drug delivery systems. It can also be used as a non-ionic surfactant for a variety of biological applications.

Application

PEGD can be used as a crosslinked hydrogel and as a substrate in tissue engineering and biomedical applications.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

753084-BULK:
753084-5G:
753084-VAR:
753084-1G:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCQ1638
MKCN1438
MKCN0038
MKCM4296
MKCL8220

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Conjugate addition reactions combined with free-radical cross-linking for the design of materials for tissue engineering
Elbert DL and Hubbell JA
Biomacromolecules, 2(2), 430-441 (2001)
Glass surfaces grafted with high-density poly (ethylene glycol) as substrates for DNA oligonucleotide microarrays
Schlapak R, et al.
Langmuir, 22(1), 277-285 (2006)
Biodegradable poly (ethylene glycol) hydrogels crosslinked with genipin for tissue engineering applications
Moffat KL and Marra KG
Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 71(1), 181-187 (2004)
Rigidity of two-component hydrogels prepared from alginate and poly (ethylene glycol)- diamines
Eiselt P, et al.
Macromolecules, 32(17), 5561-5566 (1999)
Thermal and kinetic evaluation of biodegradable thermo-sensitive gelatin/poly (ethylene glycol) diamine crosslinked citric acid hydrogels for controlled release of tramadol
Rocha-Garcia D, et al.
European Polymer Journal, 89, 42-56 (2017)
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Articles

Poly(ethylene glycol) (PEG) and Synthetic PEG Derivatives for Tissue Engineering and Cell Delivery

Highlighting new synthetic modifications of PEG to improve the mechanical properties and degradation of resulting hydrogels in tissue engineering applications.

Injectable Hydrogels for Cell Delivery and Tissue Regeneration

The use of hydrogel-based biomaterials for the delivery and recruitment of cells to promote tissue regeneration in the body is of growing interest. This article discussed the application of hydrogels in cell delivery and tissue regeneration.

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