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Safety Information

P2139

Sigma-Aldrich

Poly(ethylene glycol)

average MN 8,000, hydroxyl

Synonym(s):

Polyethylene glycol, PEG

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About This Item

Linear Formula:
H(OCH2CH2)nOH
CAS Number:
25322-68-3
MDL number:
MFCD00081839
UNSPSC Code:
12352104
PubChem Substance ID:
24898275
NACRES:
NA.23

product name

Poly(ethylene glycol), average mol wt 8,000, powder

form

powder

mol wt

average mol wt 8,000

solubility

water: soluble (PEG is soluble in water approximately 630 mg/ml, 20 °C)

density

1.0845 g/mL at 70 °C
1.0689 g/mL at 90 °C

Ω-end

hydroxyl

α-end

hydroxyl

SMILES string

C(CO)O

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

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General description

Polyethylene glycol (PEG) is a hydrophilic polymer. It can be easily synthesized by the anionic ring opening polymerization of ethylene oxide, into a range molecular weights and variety of end groups. When crosslinked into networks PEG can have high water content, forming “hydrogels”. PEG is a suitable material for biological applications because it does not trigger an immune response

Application

Poly (ethylene glycol) can be used in the formulation of the drug to improve its dissolution rate and oral bioavailability.

PEG can be used for the effective isolation of edible nanoparticles (ENPs) which have excellent anti-cancer and anti-inflammatory activities. PEG is a crowding agent and forms a net-like mesh in which nanovesicles are trapped and precipitated. For example, ginger-derived ENPs are isolated using a PEG-based method which is cost-effective compared to ultracentrifugation.

PEG can be used as a precursor to synthesize degradable hydrogels for the controlled release of hydrophilic and high molecular weight pharmaceuticals.

Features and Benefits

  • Highstructural flexibility
  • Biocompatibility
  • Amphiphilicity
  • Highhydration capacity
  • Devoidof any steric hindrance

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Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

P2139-500G:4548173205618
P2139-BULK:
P2139-1KG:4548173205595
P2139-EW:
P2139-VAR:
P2139-2KG:4548173205601

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Certificates of Analysis (COA)

Lot/Batch Number
SLCM6143
SLCM3994
SLCM0925
SLCL9206
SLCL9411

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D E Corpet et al.
Cancer research, 60(12), 3160-3164 (2000-06-24)
We have previously shown that dietary polyethylene-glycol (PEG) suppresses the occurrence of azoxymethane-induced cancers in an accelerated rat model of colon carcinogenesis. To determine the consistency of this preventive effect, we carried out a long-term study in rats fed the
Maofu Li et al.
BMC plant biology, 21(1), 57-57 (2021-01-23)
Strawberry (Fragaria × ananassa Duch.) is an important fruit crop worldwide. It was particularly sensitive to drought stress because of their fibrous and shallow root systems. Mutant rty of Arabidopsis thaliana ROOTY (RTY) results in increased endogenous auxin levels, more
Leslie Y Beh et al.
Cell, 177(7), 1781-1796 (2019-05-21)
DNA N6-adenine methylation (6mA) has recently been described in diverse eukaryotes, spanning unicellular organisms to metazoa. Here, we report a DNA 6mA methyltransferase complex in ciliates, termed MTA1c. It consists of two MT-A70 proteins and two homeobox-like DNA-binding proteins and
Lucie Vobecká et al.
New biotechnology, 47, 73-79 (2018-04-04)
Aqueous two-phase systems (ATPSs) were screened for the production of 6-aminopenicillanic acid (6-APA) catalyzed by penicillin acylase, followed by the extractive separation of 6-APA from the reaction mixture. The key point of this study was to find an ATPS exhibiting
Kento Fukano et al.
Frontiers in microbiology, 9, 3257-3257 (2019-01-24)
Current anti-hepatitis B virus (HBV) agents, which include nucleos(t)ide analogs and interferons, can significantly suppress HBV infection. However, there are limitations in the therapeutic efficacy of these agents, indicating the need to develop anti-HBV agents with different modes of action.
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