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Safety Information

N19702

Sigma-Aldrich

2-Nitrophenol

98%

Synonym(s):

2-Hydroxynitrobenzene, o-Hydroxynitrobenzene, o-Nitrophenol

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About This Item

Linear Formula:
O2NC6H4OH
CAS Number:
88-75-5
Molecular Weight:
139.11
Beilstein:
775403
EC Number:
201-857-5
MDL number:
MFCD00011688
UNSPSC Code:
12352100
PubChem Substance ID:
24897541
NACRES:
NA.22

vapor pressure

1 mmHg ( 49.3 °C)

Quality Level

200

Assay

98%

form

needles

SMILES string

Oc1ccccc1[N+]([O-])=O

InChI

1S/C6H5NO3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H

InChI key

IQUPABOKLQSFBK-UHFFFAOYSA-N

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Application

  • 2-Nitrophenol can be used in the iron-catalyzed synthesis of 2-arylbenzoxazole from benzylic alcohols.
  • It is employed in the preparation of heterodiazocines, which are potential photochromic compounds for applications in photopharmacology and functional materials.
  • It can be used as a precursor in synthesizing “off-on” chemosensor for Hg2+ detection in aqueous acetonitrile solution.
  • Additional application includes the synthesis of 1,4-benzoxazine derivative in the total synthesis of antimicrobial agent, levofloxacin.

Physical form

Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt.

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H302 + H312 + H332,H410

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

212.9 °F - closed cup

Flash Point(C)

100.5 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

N19702-BULK:
N19702-100G:
N19702-1KG:
N19702-5G:
N19702-VAR:
N19702-500G:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH1166
BCCF3584
BCCF1870
BCCC7080
BCCB2407

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Heterodiazocines: Synthesis and Photochromic Properties, Trans to Cis Switching within the Bio-optical Window.
Hammerich M, et al.
Journal of the American Chemical Society, 138(40), 13111-13114 (2016)
Hg2+-selective ratiometric and ?Off? On? chemosensor based on the azadiene? pyrene derivative.
Zhou Y, et al.
Organic Letters, 12(11), 2566-2569 (2010)
Iron-catalyzed 2-arylbenzoxazole formation from o-nitrophenols and benzylic alcohols.
Wu M, et al.
Organic Letters, 14(11), 2722-2725 (2012)
Chemoenzymatic asymmetric synthesis of 1, 4-benzoxazine derivatives: Application in the synthesis of a levofloxacin precursor.
Lopez-Iglesias M, et al.
The Journal of Organic Chemistry, 80(8), 3815-3824 (2015)
Jun Chen et al.
The journal of physical chemistry. A, 115(44), 12235-12242 (2011-10-01)
Nitrophenols and methylnitrophenols have been identified as photolytic precursors of nitrous acid, HONO, but their gas-phase absorption has not previously been reported. In this study, the absorption cross sections of 2-nitrophenol, 3-methyl-2-nitrophenol, and 4-methyl-2-nitrophenol were measured from 320 to 450
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Separation of 2-Chlorophenol; 2,4-Dichlorophenol; 2,4,6-Tribromophenol; 2,4,6-Trichlorophenol; 2,4-Dinitrophenol; Pentafluorophenol; 2-Methylphenol, analytical standard; 2,3,4,6-Tetrachlorophenol; Pentachlorophenol; 4-Nitrophenol; 2-Bromophenol; 2,3,5,6-Tetrachlorophenol; 2,3,5-Trichlorophenol; 4-Chloro-3-methylphenol; 2,4,5-Trichlorophenol; 4-Methylphenol, analytical standard; 2,4-Dimethylphenol; 2-Nitrophenol; 3-Methylphenol, analytical standard; Phenol; 2-Methyl-4,6-dinitrophenol; 2,3,4-Trichlorophenol; 2,6-Dichlorophenol; 2,3,4,5-Tetrachlorophenol

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Separation of 2-Nitrophenol; Pentachlorophenol; 2-Bromophenol; Phenol; 4-Nitrophenol; 3-Methylphenol, analytical standard; 4-Chloro-3-methylphenol; 2,4-Dichlorophenol; 2,3,4,6-Tetrachlorophenol; 2-Methylphenol, analytical standard; 2,4,6-Trichlorophenol; 2,4-Dimethylphenol; 2-Chlorophenol

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