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937177

Sigma-Aldrich

Methoxy-poly(ethylene glycol) amine-block-poly-L-lysine hydrobromide

PEG average Mn 2000, PLLA average Mn 10000

Synonym(s):

Block copolymer, Drug delivery polymer, Polymeric micelles, Tissue engineering, Tumor imaging, mPEG-amine2k -PLL10k, mPEGNH2-PLL

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About This Item

Linear Formula:
C3H9NO(OC2H4)x-(C6H13N2OBr)n
UNSPSC Code:
12162002
NACRES:
NA.21

form

powder or chunks

Quality Level

100

mol wt

PEG average Mn 2000
PLLA average Mn 10000

color

white to off-white

storage temp.

−20°C

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General description

Methoxy poly(ethylene glycol) amine-block-poly(L-lysine) (mPEG-PLL) is a cationic diblock copolymer consisting of amine-functionalized PEG and PLL that can be used in drug delivery applications to improve therapeutic efficacy. The cationic PLL block can bind to DNA or RNA, as well as other therapeutic agents, while the amine-functionalized PEG block inhibits protein adsorption and can be further functionalized with targeting moieties for targeted and controlled drug delivery. This cationic diblock copolymer can self-assemble in the presence of a drug to form polymeric micelles and polymersomes.

Application

  • Non-viral gene delivery applications
  • Targeted drug delivery applications
  • Protein coatings and tissue culture

Features and Benefits

  • Self-assemble capability to form micelles and polymersomes
  • Amine functional group at the side chain enables further rapid functionalization
  • Cationic poly(L-lysine) has excellent DNA and RNA condensation property
  • Biodegradable, biocompatible and water soluble

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

937177-500MG:
937177-VAR:
937177-BULK:

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