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Key Documents

Safety Information

934119

Sigma-Aldrich

Ovine collagen

SPDP functionalized, low endotoxin

Synonym(s):

CollOvine™-SPDP

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About This Item

CAS Number:
9007-34-5
UNSPSC Code:
12352202
NACRES:
NA.28

Quality Level

100

form

lyophilized

impurities

Bioburden, none detected
≤0.1 EU/mg Endotoxin

color

white to off-white

functional group

SPDP

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General description

Collagen is a major component of the extracellular matrix (ECM) and offers low immunogenicity, a porous structure, good permeability, and biocompatibility to promote cell viability, adhesion, spreading, proliferation and differentiation.

Low endotoxin SPDP functionalized collagen derived from ovine can be used for the covalent conjugation with sulfhydryl-containing molecules. The primary amine groups (lysine residues) of the collagen are reacted with succinimidyl 3-(2-pyridyldithio)propionate (SPDP) to yield collagen derived with a cleavable disulfide bond. The cleaved linker can react with other species containing containing free sulhydryl groups (i.e. cysteine residues) which are commonly found in many naturally occurring protein or peptide sequences.

Application

  • 3D bioprinting
  • Tissue engineering
  • Drug delivery
  • Regenerative medicine
  • Cell culture, encapsulation, expansion and differentiation

Features and Benefits

  • Certified Disease Free Sheep
  • 93-97% Type I Collagen
  • 3-7% Type III Collagen
  • 99% Purity
  • Prion Free

Legal Information

CollOvine is a trademark of OviGenex LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

934119-100MG-PW:
934119-100MG:
934119-50MG-PW:
934119-50MG:

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