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Safety Information

918652

Sigma-Aldrich

Low endotoxin alginate solution

Medium viscosity, 0.2 μm, sterile-filtered

Synonym(s):

Alginic acid, Sodium alginate

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About This Item

UNSPSC Code:
12162002
NACRES:
NA.23

Quality Level

100

sterility

sterile-filtered

form

viscous liquid

concentration

1.75-3.50 wt. % in DPBS (buffer)

impurities

<10 EU/g Endotoxin
<5 CFU/g Bioburden (Fungal)
<5 CFU/g Bioburden (Total Aerobic)

color

colorless to pale yellow

particle size

0.2 μm

pH

6.5-7.5

storage temp.

2-8°C

Application

Low endotoxin alginate solution is a 2 % low endotoxin alginate solution in DPBS buffer. It is sterile filtrated through 0.2 μm sterile filter, and ready to be used in biomedical applications.
Alginate is an anionic polysaccharide that is widely used in pharmaceutical and biomedical applications due to its non-animal origin, low toxicity, biocompatibility, and biodegradability. Alginate hydrogels are commonly used to fabricate tissue engineering scaffolds, bioinks for 3D bioprinting, and nanocarriers for drug & gene delivery. Alginate is commonly crosslinked into a hydrogel via ionic-crosslinking with divalent cations (e.g., Ca2+).

Packaging

10 mL in glass bottle

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

918652-1EA:
918652-BULK:
918652-VAR:

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Jia Jia et al.
Acta biomaterialia, 10(10), 4323-4331 (2014-07-08)
Recent advances in three-dimensional (3-D) printing offer an excellent opportunity to address critical challenges faced by current tissue engineering approaches. Alginate hydrogels have been used extensively as bioinks for 3-D bioprinting. However, most previous research has focused on native alginates
Kuen Yong Lee et al.
Progress in polymer science, 37(1), 106-126 (2011-11-30)
Alginate is a biomaterial that has found numerous applications in biomedical science and engineering due to its favorable properties, including biocompatibility and ease of gelation. Alginate hydrogels have been particularly attractive in wound healing, drug delivery, and tissue engineering applications
Tarun Agarwal et al.
ACS applied materials & interfaces, 8(47), 32132-32145 (2016-12-10)
Success of bone tissue engineering (BTE) relies on the osteogenic microarchitecture of the biopolymeric scaffold and appropriate spatiotemporal distribution of therapeutic molecules (growth factors and drugs) inside it. However, the existing technologies have failed to address both the issues together.
Eneko Axpe et al.
International journal of molecular sciences, 17(12) (2016-11-30)
Three-dimensional (3D) bioprinting is on the cusp of permitting the direct fabrication of artificial living tissue. Multicellular building blocks (bioinks) are dispensed layer by layer and scaled for the target construct. However, only a few materials are able to fulfill

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