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914487

Sigma-Aldrich

2-(Diphenylphosphanyl)benzamide

≥95%

Synonym(s):

2-(Diphenylphosphino)-benzamide, DPBM, Phosphine for Staundinger reduction

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About This Item

Empirical Formula (Hill Notation):
C19H16NOP
CAS Number:
343254-74-0
Molecular Weight:
305.31
UNSPSC Code:
12352200
NACRES:
NA.22

Quality Level

100

Assay

≥95%

form

powder

storage temp.

−20°C

General description

It is recommended to make fresh stock stolutions prior to each use.

Application

2-(Diphenylphosphanyl)benzamide (DPBM) is a phosphine useful in the Staudinger reduction in chemical biology and medicinal chemistry. Recently, DPBM was demonstrated to faciliate the reactivation of CRISPR/Cas9 functions by removing azidomethylnicotinyl (AMN) groups used to masked gRNA and inhibit CRISPR systems. AMN groups were originally added with the use of RNA probe NAI-N3 (cat# 913812).

Other Notes

Conditional control of RNA-guided nucleic acid cleavage and gene editing

Small-molecule control of protein function through Staudinger reduction

A FRET-based ratiometric two-photon fluorescent probe for dual-channel imaging of nitroxyl in living cells and tissues

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

914487-50MG:
914487-VAR:
914487-BULK:
914487-250MG:

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Ji Luo et al.
Nature chemistry, 8(11), 1027-1034 (2016-10-22)
Using small molecules to control the function of proteins in live cells with complete specificity is highly desirable, but challenging. Here we report a small-molecule switch that can be used to control protein activity. The approach uses a phosphine-mediated Staudinger

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