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270253

Sigma-Aldrich

4-Hydroxybenzamide

98%

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About This Item

Linear Formula:
HOC6H4CONH2
CAS Number:
619-57-8
Molecular Weight:
137.14
EC Number:
210-602-7
MDL number:
MFCD00007997
UNSPSC Code:
12352100
PubChem Substance ID:
24856366
NACRES:
NA.22

Assay

98%

mp

161-162 °C (lit.)

SMILES string

NC(=O)c1ccc(O)cc1

InChI

1S/C7H7NO2/c8-7(10)5-1-3-6(9)4-2-5/h1-4,9H,(H2,8,10)

InChI key

QXSAKPUBHTZHKW-UHFFFAOYSA-N

Related Categories

General description

The standard molar enthalpy of formation of 4-hydroxybenzamide was studied by micro- or macrocombustion calorimetry.

Application

4-Hydroxybenzamide was used in the synthesis of balanol, a potent protein kinase C (PKC) inhibitor.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

270253-25G:
270253-5G:
270253-VAR:
270253-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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R S Randad et al.
Bioorganic & medicinal chemistry, 4(9), 1471-1480 (1996-09-01)
A combination of structure-activity studies, kinetic analysis, X-ray crystallographic analysis, and modeling were employed in the design of a novel series of HIV-1 protease (HIV PR) inhibitors. The crystal structure of a complex of HIV PR with SRSS-2,5-bis[N-(tert-butyloxycarbonyl)amino]-3,4-dihydroxy-1, 6-diphenylhexane (1)
G D Hartman et al.
Bioorganic & medicinal chemistry letters, 9(6), 863-868 (1999-04-17)
A new series of potent, linearly-minimized, orally active, selective GPIIb/IIIa inhibitors is identified. Thus 15 (L-750,034) achieves interaction via a constrained, non-turned conformation that maintains the proper distance between its charged termini and full sulfonamide exosite interaction. The diminutive stature
C Emoto et al.
Xenobiotica; the fate of foreign compounds in biological systems, 37(12), 1408-1420 (2007-10-19)
CJ-036878, N-(3-phenethoxybenzyl)-4-hydroxybenzamide, was developed as an antagonist of the N-methyl-D-aspartate receptor NR2B subunit. Two dimeric metabolites, CJ-047710 and CJ-047713, were identified from the incubation mixture with CJ-036878 in human liver microsomes (HLM). The identification of the enzymes involved in the
Carlos E S Bernardes et al.
The journal of physical chemistry. A, 112(40), 10029-10039 (2008-09-13)
The energetics of the phenolic O-H bond in a series of 2- and 4-HOC 6H 4C(O)Y (Y = H, CH3, CH 2CH=CH2, C[triple bond]CH, CH2F, NH2, NHCH 3, NO2, OH, OCH3, OCN, CN, F, Cl, SH, and SCH3) compounds and
G D Smith et al.
Protein science : a publication of the Protein Society, 5(8), 1502-1511 (1996-08-01)
The structure of a symmetric T3R3f insulin hexamer, complexed with 4-hydroxybenzamide, has been determined using X-ray crystallographic techniques. Data were measured from six crystals grown in microgravity to a resolution of 1.4 A and the structure has been refined including
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