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Safety Information

141038

Sigma-Aldrich

2-Hydroxybenzonitrile

99%

Synonym(s):

2-Cyanophenol, Salicylonitrile

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About This Item

Linear Formula:
NCC6H4OH
CAS Number:
611-20-1
Molecular Weight:
119.12
Beilstein:
1210029
EC Number:
210-259-3
MDL number:
MFCD00002145
UNSPSC Code:
12352100
PubChem Substance ID:
24848487
NACRES:
NA.22

Quality Level

100

Assay

99%

form

powder

bp

149 °C/14 mmHg (lit.)

mp

92-95 °C (lit.)

functional group

nitrile

SMILES string

Oc1ccccc1C#N

InChI

1S/C7H5NO/c8-5-6-3-1-2-4-7(6)9/h1-4,9H

InChI key

CHZCERSEMVWNHL-UHFFFAOYSA-N

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Application

2-Hydroxybenzonitrile may be used in the preparation of:
  • methyl-(2-cyanophenoxy)acetate
  • 3-amino-N-phenylbenzofuran-2-carboxamide
  • 2-(2-oxo-2-phenylethoxy)benzonitrile
  • 3-amino-2-cyanobenzo[b]furane
It may also be used as a directing group for meta-selective C-H bond alkenylation.
2-Hydroxybenzonitrile was used as starting reagent during the synthesis of:
  • mono-alkoxyphenyloxazoline
  • furanoside

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H302,H317,H318

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Sens. 1B

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Deleterious substance

JAN Code

141038-5G:4548173105246
141038-BULK:
141038-VAR:
141038-25G:4548173105239
141038-1G:4548173105222

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Certificates of Analysis (COA)

Lot/Batch Number
STBJ5909
STBH1960
STBF3940V
STBD9339V
STBD1055V

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Reactivity of 1, 2-cyclic sulfite xylosides towards nucleophiles.
Batoux N, et al.
Tetrahedron, 65(43), 8858-8862 (2009)
Enantioselective Cu-catalyzed 1, 4-addition of Me3Al to a 4, 4-disubstituted cyclohexa-2, 5-dienone.
Takemoto Y, et al.
Tetrahedron, 52(45), 14177-14188 (1996)
Efficient New Synthesis of N-Arylbenzo [b] furo [3, 2-d] pyrimidin-4-amines and Their Benzo [b] thieno [3, 2-d] pyrimidin-4-amine Analogues via a Microwave-Assisted Dimroth Rearrangement.
Loidreau Y, et al.
Journal of Heterocyclic Chemistry, 50(5), 1187-1197 (2013)
Synthesis, Anticonvulsant and Neurotoxicity Evaluation of Some Newer N-(2-benzoylbenzofuran-3-yl)-3-(substituted)-propanamide Analogs.
Kamal M, et al.
Central Nervous System Agents in Medicinal Chemistry, 13(3), 159-165 (2013)
1, 3-Dipolar Cycloaddition in the Preparation of New Fused Heterocyclic Compounds via Thermal Initiation.
Porubsky M, et al.
Molecules (Basel), 21(2), 187-187 (2016)
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