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219428

Sigma-Aldrich

4-Fluoroiodobenzene

99%

Synonym(s):

1-Fluoro-4-iodobenzene, 1-Iodo-4-fluorobenzene, 4-Fluoro-1-iodobenzene, 4-Fluorophenyl iodide, 4-Iodo-1-fluorobenzene, 4-Iodofluorobenzene, p-Fluoroiodobenzene, p-Fluorophenyl iodide, p-Iodofluorobenzene

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About This Item

Linear Formula:
FC6H4I
CAS Number:
352-34-1
Molecular Weight:
222.00
EC Number:
206-522-7
MDL number:
MFCD00001052
UNSPSC Code:
12352100
PubChem Substance ID:
24853127
NACRES:
NA.22

Assay

99%

form

liquid

contains

copper as stabilizer

refractive index

n20/D 1.583 (lit.)

bp

182-184 °C (lit.)

mp

−20 °C (lit.)

density

1.925 g/mL at 25 °C (lit.)

SMILES string

Fc1ccc(I)cc1

InChI

1S/C6H4FI/c7-5-1-3-6(8)4-2-5/h1-4H

InChI key

KGNQDBQYEBMPFZ-UHFFFAOYSA-N

General description

4-[18F] Fluoroiodobenzene is a versatile building block in 18F radiochemistry and is used in various transition metal-mediated C-C and C-N cross-coupling reactions. Cross-coupling reaction of 4-fluoroiodobenzene with potassium pentafluorophenyltrifluoroborate in the presence of different palladium catalysts and silver oxide in toluene has been investigated.

Application

4-Fluoroiodobenzene was used in the preparation of fluorotriphenylene derivatives.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

154.4 °F - closed cup

Flash Point(C)

68 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 2 petroleums
Hazardous rank III
Water insoluble liquid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

219428-BULK:
219428-VAR:
219428-10G:
219428-5G:4548173986654
219428-50G:4548173986661

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Thiruvellore Thatai Jayanth et al.
Chemical communications (Cambridge, England), (8)(8), 894-896 (2006-02-16)
Highly substituted triphenylene derivatives were prepared in good yields via the palladium-catalyzed carbocyclization of arynes with aryl iodides.
The effect of N-heterocyclic carbene ligands in the palladium-catalyzed cross-coupling reaction of K [C6F5BF3] with aryl iodides and aryl bromides.
Adonin NY, et al.
Tetrahedron, 64(25), 5920-5924 (2008)
Jenilee Dawn Way et al.
Journal of labelled compounds & radiopharmaceuticals, 57(2), 104-109 (2014-03-29)
4-[18F]Fluoroiodobenzene ([18F]FIB) is a versatile building block in 18F radiochemistry used in various transition metal-mediated C-C and C-N cross-coupling reactions and [18F]fluoroarylation reactions. Various synthesis routes have been described for the preparation of [18F]FIB. However, to date, no automated synthesis
Gabriel A Odugbesi et al.
Journal of chromatography. A, 1604, 460466-460466 (2019-09-03)
Ionic liquids (ILs) are well-known in the field of separation science for their unique selectivity when used as stationary phases in gas chromatography (GC). While a significant amount of knowledge has been attained in correlating structural features of an IL

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