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V900422

Sigma-Aldrich

Folic acid

Vetec™, reagent grade, ≥97%

Sinonimo/i:

PteGlu, Pteroyl-L-glutamic acid, Vitamin M

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About This Item

Formula empirica (notazione di Hill):
C19H19N7O6
Numero CAS:
59-30-3
Peso molecolare:
441.40
Beilstein:
100781
Numero CE:
200-419-0
Numero MDL:
MFCD00079305
Codice UNSPSC:
12352106
ID PubChem:
329829830

Grado

reagent grade

Nome Commerciale

Vetec™

Saggio

≥97%

Stato

powder

tecniche

HPLC: suitable

Colore

yellow to orange

Punto di fusione

>285 °C

Stringa SMILE

NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O

InChI

1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
OVBPIULPVIDEAO-LBPRGKRZSA-N

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Descrizione generale

Folic acid belongs to vitamin B group and is also called as vitamin B9 or folate. It is present as 5-methyltetrahydrofolate in humans. Grains, fruits and vegetables are dietary sources of folate. Pteroylmonoglutamate is a synthetic folate which comprises single glutamate and exists in the oxidized state.

Azioni biochim/fisiol

Folic acid is essential for cell growth, brain functioning and plays a key role on serine production from glycine. It also coordinates with vitamin B12 in maintaining iron levels. Deficiency of folate is implicated in megaloblastic anemia. Folic acid aids in the repair and synthesis of DNA. Dietary supplementation and fortification of folate in foods is recommended for pregnant women especially in the first trimester to avoid congenital malformation and neural tube defects (NTDs). However, folate fortification may also impose a moderate risk of developing prostate cancer. Supplementation of folate to colon cancer cells diminishes iron levels and impairs the cell division.

Note legali

Vetec is a trademark of Merck KGaA, Darmstadt, Germany

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

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Certificati d'analisi (COA)

Lot/Batch Number
WXBD2527V
WXBC7820V
WXBC7507V
WXBC6954V
WXBB1324V

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Folic acid supplementation for pregnant women and those planning pregnancy: 2015 update
Chitayat D, et al.
Journal of Clinical Pharmacology, 56(2), 170-175 (2016)
High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells
Pellis L, et al.
The British Journal of Nutrition, 99(4), 703-708 (2008)
Cancer risk with folic acid supplements: a systematic review and meta-analysis
Wien TN, et al.
BMJ Open, 2(1), e000653-e000653 (2012)
The metabolic processes of folic acid and Vitamin B12 deficiency
Mahmood L
Journal of Health Research and Reviews, 1(1), 5-5 (2014)
Tor A Strand et al.
Pediatrics, 135(4), e918-e926 (2015-03-25)
Folate and vitamin B-12 are important for growth. Many children in low- and middle-income countries have inadequate intakes of these nutrients. We undertook a randomized, placebo controlled double-blind trial in 1000 North Indian children, 6 to 35 months of age
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