F7876

Folic acid

≥97%

• Sinonimo/i: PteGlu, Pteroyl-L-glutamic acid, Vitamin M
• Formula empirica (notazione di Hill): C₁₉H₁₉N₇O₆
• Numero CAS: 59-30-3
• Peso molecolare: 441.40
• Beilstein: 100781
• Numero CE: 200-419-0
• Numero MDL: MFCD00079305
• Codice UNSPSC: 12352106
• eCl@ss: 34058014
• ID PubChem: 57654192
• NACRES: NA.79

Proprietà

• Origine biologica: synthetic (organic)
• Saggio: ≥97%
• Stato: powder
• tecniche: HPLC: suitable
• Colore: faint orange to dark orange-yellow; faint yellow to dark yellow
• Punto di fusione: >285 °C
• Temperatura di conservazione: room temp
• Stringa SMILE: NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O
• InChI: 1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1; OVBPIULPVIDEAO-LBPRGKRZSA-N

Descrizione

Applicazioni

Folic acid has been used:

• to induce acute kidney injury in mice
• as a supplement to cultivate MCF-7 breast cancer cells.
• to construct folate or TNF-related apoptosis-including ligand (TRAIL)-conjugated nanomicelles

Azioni biochim/fisiol

Enzyme cofactor essential for the synthesis, methylation, and repair of DNA. Folic acid supplements may reduce colorectal cancer risk.

Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon′ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)