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Key Documents

Altri documenti

W1895

Sigma-Aldrich

WAY-100135

≥98% (HPLC)

Sinonimo/i:

3-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-phenyl-N-tert-butyl-propanamide dihydrochloride;, N-tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl) -2-phenylpropanamide dihydrochloride

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About This Item

Formula empirica (notazione di Hill):
C24H33N3O2 · 2HCl
Numero CAS:
149055-79-8
Peso molecolare:
468.46
Numero MDL:
MFCD00903910
Codice UNSPSC:
12352200
ID PubChem:
329830428
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

white to off-white

Solubilità

H2O: ≥10 mg/mL

Ideatore

Wyeth

Temperatura di conservazione

2-8°C

Stringa SMILE

Cl.Cl.COc1ccccc1N2CCN(CC2)CC(C(=O)NC(C)(C)C)c3ccccc3

InChI

1S/C24H33N3O2.2ClH/c1-24(2,3)25-23(28)20(19-10-6-5-7-11-19)18-26-14-16-27(17-15-26)21-12-8-9-13-22(21)29-4;;/h5-13,20H,14-18H2,1-4H3,(H,25,28);2*1H
VJGZNBYDSDEOED-UHFFFAOYSA-N

Azioni biochim/fisiol

WAY-100135 is a potent, selective 5-HT1A receptor antagonist (IC50 = 15 nM). It is selective over 5-HT1B, 1C, 2,α1, α2 and D2 receptors (IC50 > 1000 nM).

Caratteristiche e vantaggi

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Kangjian Xiang et al.
Current neurovascular research, 13(4), 321-328 (2016-10-26)
Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter that modulates N-methyl-D-aspartate (NMDA) receptor activity by binding to several different 5-HT receptor subtypes. In the present study, we used whole-cell patch-clamp recordings in transverse slice preparations to test the role of 5-HT
Daniel Sobrido-Cameán et al.
Disease models & mechanisms, 12(2) (2019-02-03)
Classical neurotransmitters are mainly known for their roles as neuromodulators, but they also play important roles in the control of developmental and regenerative processes. Here, we used the lamprey model of spinal cord injury to study the effect of serotonin
Lei Han et al.
The Journal of physiology, 599(1), 253-267 (2020-10-03)
Chemogenetic activation of medial vestibular nucleus-projecting 5-HT neurons resulted in deficits in vestibular-mediated tasks, including negative geotaxis, balance beam and rota-rod tests. The 5-HT1A receptor mediates the vestibular-related behavioural effects of 5-HT in the vestibular nucleus. 5-HT1A receptor activation attenuated

Articoli

Serotonin Receptors

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