U5377

Uracil 1-β-D-arabinofuranoside

lymphoma antiproliferative

• Sinonimo/i: Arauridine, Spongouridin, 1-β-D-Arabinofuranosyluracil
• Formula empirica (notazione di Hill): C₉H₁₂N₂O₆
• Numero CAS: 3083-77-0
• Peso molecolare: 244.20
• Beilstein: 28749
• Numero CE: 221-386-9
• Numero MDL: MFCD00065998
• Codice UNSPSC: 41106305
• ID PubChem: 24900655
• NACRES: NA.51

Proprietà

• Origine biologica: synthetic (organic)
• Livello qualitativo: 200
• Saggio: ≥98% (HPLC)
• Stato: powder
• Solubilità: water: 50 mg/mL, clear, colorless
• Temperatura di conservazione: −20°C
• Stringa SMILE: OC[C@H]1O[C@H]([C@@H](O)[C@@H]1O)N2C=CC(=O)NC2=O
• InChI: 1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7+,8-/m1/s1; DRTQHJPVMGBUCF-CCXZUQQUSA-N

Descrizione

Descrizione generale

1-β-d-arabinofuranosyluracil (Ara-U) is the detoxification product or metabolite of 1-β-d-arabinofuranosylcytosine (Ara-C). Uracil 1-β-D-arabinofuranoside is the human metabolite of a cytostatic agent called cytarabine (CYT).

Applicazioni

Uracil 1-β-D-arabinofuranoside may be used as a reference compound in the analysis of cytostatics and metabolites in hospital wastewater by hydrophilic interaction chromatography/tandem mass spectrometry to demonstrate its analytical possibilities and limitations. It may also be used as a standard for chemical analysis to investigate the ecotoxicity and genotoxicity of cytotoxic antineoplastic drugs, like cytarabine (CYT) and their metabolites, like uracil-1-β-d-arabinofuranoside (AraU).

Azioni biochim/fisiol

1-β-D-Arabinofuranosyluracil (ara-U) is capable of inhibiting proliferation of L5178Y mouse lymphoma cells at 17 μM concentration.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)