U4010
Urokinase from human kidney cells
lyophilized powder
Sinonimo/i:
u-Plasminogen activator
Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
About This Item
Prodotti consigliati
Livello qualitativo
Forma fisica
lyophilized powder
PM
heavy chain 30,400 Da
light chain 2000 Da
Temperatura di conservazione
2-8°C
Cerchi prodotti simili? Visita Guida al confronto tra prodotti
Applicazioni
Urokinase from human kidney cells has been used as a component of digestion mix for three-dimensional fibrin culture. It has also been used in plasminogen activation assay.
Azioni biochim/fisiol
Urokinase is a protease that cleaves plasminogen to form plasmin. It binds to cell surface receptors (uPAR) from which it regulates cell adhesion and migration during tissue remodeling and which also activate intracellular signaling pathways. Urokinase is composed of three domains: the amino terminal domain which is homologous to epidermal growth factor is attached through a central kringle domain to the protease domain in the carboxyl terminus.
Urokinase was shown to augment proliferation of renal tumor cells.
Proprietà fisiche
Supplied as a lyophilized powder containing human albumin, mannitol and NaCl.
The principle active ingredient is the low molecular weight form of urokinase, and consists of an A chain of 2,000 daltons linked by a sulfhydyl bond to a B chain of 30,400 daltons.
Altre note
Note: Higher activities are obtained when human plasminogen is used as substrate.
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Resp. Sens. 1
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
I clienti hanno visto anche
The multifaceted roles of Leptospira enolase
Salazar N, et al.
Research in Microbiology, 168(2), 157-164 (2017)
J C Kirchheimer et al.
Carcinogenesis, 9(11), 2121-2123 (1988-11-01)
Primary cultures of renal cell carcinomas and of the corresponding normal adjacent kidney tissue from 6 patients were analyzed for the effects of exogenously added urokinase-type plasminogen activator on cell proliferation as compared to the effects of tissue type plasminogen
Hematopoietic-to-mesenchymal transition of adipose tissue macrophages is regulated by integrin beta and fabricated fibrin matrices
Gavin KM, et al.
Adipocyte, 6(3), 234-249 (2017)
H R Lijnen et al.
The Journal of biological chemistry, 265(9), 5232-5236 (1990-03-25)
The mechanism of the activation of plasminogen by single-chain urokinase-type plasminogen activator (single-chain u-PA, scu-PA) was studied using rscu-PA-Glu158, a recombinant plasmin-resistant mutant of human scu-PA obtained by site-specific mutagenesis of Lys158 to Glu, and rPlg-Ala740, a recombinant human plasminogen
Helena Enocsson et al.
Translational research : the journal of laboratory and clinical medicine, 162(5), 287-296 (2013-08-07)
Assessments of disease activity and organ damage in systemic lupus erythematosus (SLE) remain challenging because of the lack of reliable biomarkers and disease heterogeneity. Ongoing inflammation can be difficult to distinguish from permanent organ damage caused by previous flare-ups or
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica.