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T3258

Sigma-Aldrich

Tetracycline

98.0-102.0% (HPLC)

Sinonimo/i:

Tetracycline Hydrate

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About This Item

Formula empirica (notazione di Hill):
C22H24N2O8 · xH2O
Numero CAS:
60-54-8
Peso molecolare:
444.43 (anhydrous basis)
Beilstein:
2230417
Numero CE:
200-481-9
Numero MDL:
MFCD00151232
Codice UNSPSC:
51284017
ID PubChem:
24900120
NACRES:
NA.85

Livello qualitativo

200

Saggio

98.0-102.0% (HPLC)

Forma fisica

powder or crystals

Condizioni di stoccaggio

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

Colore

faint yellow to dark yellow

Spettro attività antibiotica

Gram-negative bacteria
Gram-positive bacteria

Modalità d’azione

protein synthesis | interferes

Temperatura di conservazione

2-8°C

Stringa SMILE

CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O

InChI

1S/C22H24N2O8/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30)/t9-,10-,15-,21+,22-/m0/s1
OFVLGDICTFRJMM-WESIUVDSSA-N

Informazioni sul gene

human ... CYP1A2(1544) , TERT(7015)

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Descrizione generale

Chemical structure: tetracycline

Azioni biochim/fisiol

Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.

Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.

Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.

Altre note

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place

Avvertenze

Warning

Indicazioni di pericolo

H302,H361fd,H411

Classi di pericolo

Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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