T2573

Troglitazone

≥98% (HPLC), powder, PPARγ agonist

• Sinonimo/i: (±)-5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione, CS-045
• Formula empirica (notazione di Hill): C₂₄H₂₇NO₅S
• Numero CAS: 97322-87-7
• Peso molecolare: 441.54
• Numero MDL: MFCD00878416
• Codice UNSPSC: 12352200
• ID PubChem: 24724629
• NACRES: NA.77

Proprietà

• Nome del prodotto: Troglitazone, ≥98% (HPLC)
• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to off-white
• Solubilità: DMSO: 20 mg/mL
• Stringa SMILE: Cc1c(C)c2OC(C)(CCc2c(C)c1O)COc3ccc(CC4SC(=O)NC4=O)cc3
• InChI: 1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28); GXPHKUHSUJUWKP-UHFFFAOYSA-N
• Informazioni sul gene: human ... PPARA(5465) , PPARG(5468)

Descrizione

Descrizione generale

Troglitazone is used to treat type 2 diabetes. It is associated with liver injury. Troglitazone functions as an inducer of cytochrome3A.

Applicazioni

Troglitazone has been used as a reagent in adipocyte differentiation medium.

Azioni biochim/fisiol

PPARγ agonist; anti-diabetic thiazolidinedione (TZD) with anti-inflammatory and anti-tumor activity; induces apoptosis via a p53 pathway.

Caratteristiche e vantaggi

This compound is featured on the Nuclear Receptors (PPARs) and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota sulla preparazione

Studies using troglitazone have reported that it can increase AMP-activated protein kinase (pAMPK) and phosphorylated acetyl-CoA carboxylase in isolated rat extensor digitorum longus muscles¹. Furthermore, analysis of troglitazone-mediated autophagy is reported to correlate with the stimulation of AMPK α².

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)