T2455

T3MG

• Sinonimo/i: (±)-threo-3-Methylglutamic acid, 3MG, threo-3-Methylglutamate
• Formula empirica (notazione di Hill): C₆H₁₁NO₄
• Numero CAS: 63088-04-0
• Peso molecolare: 161.16
• Numero MDL: MFCD09836097
• Codice UNSPSC: 12352200
• ID PubChem: 329826708
• NACRES: NA.77

Proprietà

• Forma fisica: powder
• Livello qualitativo: 100
• Colore: white to off-white
• Solubilità: H₂O: >1.5 mg/dL
• Compatibilità: suitable for TLC (single spot)
• Temperatura di conservazione: room temp
• Stringa SMILE: C[C@@H](CC(O)=O)[C@@H](N)C(O)=O
• InChI: 1S/C6H11NO4/c1-3(2-4(8)9)5(7)6(10)11/h3,5H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,5+/m0/s1; FHJNAFIJPFGZRI-WVZVXSGGSA-N

Descrizione

Azioni biochim/fisiol

T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4. T3MG has long been utilized as a gold standard in the study of general EAAT function. It has more recently been shown to be selective for EAAT2 and EAAT4 as compared to EAAT1 and EAAT3 in electrophysiology and glutamate/aspartate uptake assays. Although there are other EAAT2-selective compounds, this is the first tool with selectivity for EAAT4. T3MG is not a substrate for the transporters themselves, nor does it have activity at glutamate ion channels.

Caratteristiche e vantaggi

This compound is featured on the Excitatory Amino Acid Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota sulla preparazione

T3MG dissolves in water at a concentration that is greater than 1.5 mg/ml.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H315 - H319 - H335
• Consigli di prudenza: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable