T0452
D-α-Tocotrienol
from rice, ≥75% (GC)
Sinonimo/i:
3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2H-1-benzopyran-6-ol
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About This Item
Formula empirica (notazione di Hill):
C29H44O2
Numero CAS:
Peso molecolare:
424.66
Codice UNSPSC:
12352205
NACRES:
NA.79
Prodotti consigliati
Origine biologica
rice
Livello qualitativo
Saggio
≥75% (GC)
Stato
liquid
Colore
colorless to brown
Punto di fusione
30-31 °C
Temperatura di conservazione
−20°C
Stringa SMILE
O1[C@@](CCc2c1c(c(c(c2C)O)C)C)(CC\C=C(\CC\C=C(\CCC=C(C)C)/C)/C)C
InChI
1S/C29H44O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h12,14,16,30H,9-11,13,15,17-19H2,1-8H3/b21-14+,22-16+/t29-/m1/s1
RZFHLOLGZPDCHJ-XZXLULOTSA-N
Categorie correlate
Descrizione generale
Tocotrienols belong to the vitamin E family and have an unsaturated isoprenoid side chain. The various isoforms of tocotrienols differ in their methyl substitution in the chromanol head. α-Tocotrienol present in crude palm oil is regarded as a natural supplement.
Azioni biochim/fisiol
α-Tocotrienol is an effective free radical scavengerand elicits protective functionality during oxidative stress in microsomes. It is a strong antioxidant, which reduces inflammation and is used in cancer treatment. α-tocotrienol supplementation may reduce cholesterol levels in hypercholesterolemia. α-tocotrienol is neuroprotective as it blocks glutamate-induced cell death in neuronal cells.
α-Tocotrienol may be used along with other isoforms to differentiate tocotrienol activities.
Tocotrienols are widely utilized for their strong antioxidant properties. The various isoforms of tocotrienols differ in their methyl substitution in the chromanol head. α-tocotrienol demonstrates neuroprotective properties by blocking glutamate-induced cell death in neuronal cells.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I clienti hanno visto anche
Yoshiro Saito et al.
Free radical biology & medicine, 49(10), 1542-1549 (2010-08-26)
Glutamate plays a critical role in pathological cell death within the nervous system. Vitamin E is known to protect cells from glutamate cytotoxicity, either by direct antioxidant action or by indirect nonantioxidant action. Further, α-tocotrienol (α-T3) has been reported to
Savita Khanna et al.
Journal of neurochemistry, 98(5), 1474-1486 (2006-08-23)
The natural vitamin E tocotrienols possess properties not shared by tocopherols. Nanomolar alpha-tocotrienol, not alpha-tocopherol, is potently neuroprotective. On a concentration basis, this finding represents the most potent of all biological functions exhibited by any natural vitamin E molecule. We
Tocotrienol is a cardioprotective agent against ageing-associated cardiovascular disease and its associated morbidities
Ramanathan N, et al.
Nutrition & Metabolism, 15(1), 6-6 (2018)
Han-A Park et al.
Stroke, 42(8), 2308-2314 (2011-07-02)
α-Tocotrienol (TCT) represents the most potent neuroprotective form of natural vitamin E that is Generally Recognized As Safe certified by the U.S. Food and Drug Administration. This work addresses a novel molecular mechanism by which α-TCT may be protective against
Kailash Prasad
Current pharmaceutical design, 17(21), 2147-2154 (2011-07-22)
This review emphasizes the effects of tocotrienols on the risk factors for atherosclerosis, plaque instability and thrombogenesis, and compares these effects with tocopherol. Tocotrienols reduce serum lipids and raise serum HDL-C. Alpha-tocopherol, on the other hand, has no effect on
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