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Key Documents

SRP8056

Sigma-Aldrich

Tim-3 (mouse): FC (human)

recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)

Sinonimo/i:

HAVcr-2, T-cell immunoglobulin and mucin domain-containing protein 3, TIM3, TIMD3

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About This Item

Codice UNSPSC:
12352200
NACRES:
NA.32

Origine biologica

mouse

Ricombinante

expressed in CHO cells

Saggio

≥98% (SDS-PAGE)

Forma fisica

lyophilized

PM

monomer 45 kDa by calculation

Confezionamento

pkg of 100 μg

Condizioni di stoccaggio

avoid repeated freeze/thaw cycles

Impurezze

<0.06 EU/μg endotoxin, tested

Colore

white

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

mouse ... Havcr2(171285)

Descrizione generale

Tim-3 is a type I transmembrane protein. It contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. TIM-3 is preferentially expressed on Type 1 T-helper (Th1) and Type 1 CD8+ T (Tc1) cells. TIM-3 is also expressed on some dendritic cells. The gene encoding this protein is localized on mouse chromosome 11B1.1.

Azioni biochim/fisiol

The T cell/transmembrane, immunoglobulin and mucin (TIM) family plays a crucial role in regulating immune responses, such as allergy, asthma, transplant tolerance, autoimmunity and also has a control over the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. Tim-3 generates an inhibitory signal resulting in apoptosis of Type 1 T-helper (Th1) and Type 1 CD8+ T (Tc1) cells. It can also mediate phagocytosis of apoptotic cells and cross-presentation of antigen. It functions to inhibit aggressive Th1-mediated auto- and allo-immune responses. Tim-3 pathway blockade by administration of Tim-3: Fc fusion protein accelerates diabetes in non-obese diabetic mice, causes hyperproliferation of Th1 cells and Th1 cytokine release in an experimental autoimmune encephalomyelitis (EAE) model and prevents acquisition of transplantation tolerance induced by costimulation blockade.

Stato fisico

Lyophilized from 0.2 μm-filtered solution in PBS.

Ricostituzione

Reconstitute at 100 μg/mL in sterile PBS.

Altre note

The extracellular domain of mouse Tim-3 (aa 21-189) is fused to the N-terminus of the Fc region of human IgG1.

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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TIM-3 is Expressed on Activated Human CD4+ T Cells and Regulates Th1 and Th17 Cytokines
William D. Hastings
European Journal of Immunology, 39(9), 2492-2501 (2009)
TIM Proteins and Immunity
Lawrence P. Kane
Journal of Immunology, 184(6), 2743-2749 (2010)
T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice
Roselyn R
Proceedings of the National Academy of Sciences of the USA, 107.19, 8706-8711 (2010)
TIM-1 and TIM-3 Proteins in Immune Regulation
Ee Wern Su
Cytokine, 44(1), 9-13 (2008)
TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity
Gordon J. Freeman
Immunological Reviews, 235(1), 172-189 (2010)

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