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Merck
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Documenti fondamentali

SRP8015

Sigma-Aldrich

Progranulin mouse

>95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized

Sinonimo/i:

GPx-1, PEPI, Proepithelin

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About This Item

Codice UNSPSC:
12352202
NACRES:
NA.32

product name

Progranulin mouse, recombinant, expressed in HEK 293 cells, untagged, >95% (SDS-PAGE)

Origine biologica

mouse

Ricombinante

expressed in HEK 293 cells

Coniugato

untagged

Saggio

>95% (SDS-PAGE)

Forma fisica

lyophilized

PM

~65 kDa by SDS-PAGE

Confezionamento

pkg of 10 μg

Impurezze

<0.1 EU/μg endotoxin, tested

Colore

white

N° accesso UniProt

P28798

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

mouse ... Grn(14824)

Descrizione generale

Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer′s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

Stato fisico

Lyophilized from 0.2 μm-filtered solution in PBS, pH 7.2.

Ricostituzione

Reconstitute with 100 μL deionized water.

Altre note

Signal peptide and mouse progranulin (aa 1-589) is untagged. Reflects the native sequence with no additional aa.

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Lorenz Thurner et al.
Digestive diseases and sciences, 59(8), 1733-1742 (2014-03-05)
Recently, we identified neutralizing autoantibodies against progranulin (PGRN) in a wide spectrum of rheumatic diseases including cases with enteropathic spondylarthritis. PGRN is a secreted protein with strong anti-inflammatory effects, believed to be mediated by the direct inhibition of TNF receptors
Masato Kanazawa et al.
Brain : a journal of neurology, 138(Pt 7), 1932-1948 (2015-04-04)
In the central nervous system, progranulin, a glycoprotein growth factor, plays a crucial role in maintaining physiological functions, and progranulin gene mutations cause TAR DNA-binding protein-43-positive frontotemporal lobar degeneration. Although several studies have reported that progranulin plays a protective role
Michael J Smout et al.
PLoS pathogens, 11(10), e1005209-e1005209 (2015-10-21)
Infection with the human liver fluke Opisthorchis viverrini induces cancer of the bile ducts, cholangiocarcinoma (CCA). Injury from feeding activities of this parasite within the human biliary tree causes extensive lesions, wounds that undergo protracted cycles of healing, and re-injury

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