SRP6170

IL-2 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

• Sinonimo/i: Aldesleukin, Lymphokine, N/A, T-cell growth factor (TCGF)
• Numero CAS: 110942-02-4
• Codice UNSPSC: 12352202
• NACRES: NA.32

Proprietà

• Origine biologica: human
• Ricombinante: expressed in HEK 293 cells
• Saggio: ≥95% (SDS-PAGE)
• Stato: lyophilized
• Potenza: 0.2-2 ng/mL
• PM: 15 kDa (monomer, glycosylated)
• Confezionamento: pkg of 10 μg
• tecniche: cell culture | mammalian: suitable
• N° accesso NCBI: P60568
• N° accesso UniProt: P60568
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −70°C
• Informazioni sul gene: human ... IL2(3558)

Descrizione

Descrizione generale

IL-2 (interleukin 2) is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. It is a type I cytokine. Recombinant human IL-2 is a 15.5kDa protein, containing 134 amino acid residues including one intrachain disulfide bond.

The IL-2 gene is mapped to human chromosome 4q27.

Applicazioni

IL-2 (interleukin 2) human has been used for the stimulation of human primary naive T lymphocytes to study the effect of microRNA-146a on IL-2 activation-induced cell death.

Azioni biochim/fisiol

IL-2/IL-2R (interleukin 2/IL-2 receptor) signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK (natural killer) cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. It is associated with recurrent oral ulcer and asthma and Mycoplasma pneumoniae infection in children. Absence of IL-2 in mice causes fatal lymphoproliferative inflammatory disease (IL-2 deficiency syndrome). IL-2 signaling involves three pathways: phosphoinositol 3-kinase (PI3-K)/AKT, Ras-MAPK (mitogen activated protein kinase), and JAK-STAT (Janus kinase - signal transducers and activators of transcription) pathways.

Stato fisico

Lyophilized from a PBS solution.

Nota sulla preparazione

Centrifuge the vial prior to opening.

Ricostituzione

Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable