SRP5218
EIF2AK4 (192-1024), active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sinonimo/i:
GCN2, KIAA1338
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About This Item
Codice UNSPSC:
12352200
NACRES:
NA.32
Prodotti consigliati
Ricombinante
expressed in baculovirus infected Sf9 cells
Nome Commerciale
PRECISIO® Kinase
Saggio
≥70% (SDS-PAGE)
Stato
buffered aqueous glycerol solution
Attività specifica
11.9-16.1 nmol/min·mg
PM
~132 kDa
N° accesso NCBI
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
Informazioni sul gene
human ... EIF2AK4(440275)
Descrizione generale
Eukaryotic translation initiation factor 2-α kinase 4 (EIF2AK4), also known as GCN2 is an enzyme encoded by EIF2AK4 gene in humans. In mouse, EIF2AK4 is widely expressed with prominent expression in liver and brain.
Azioni biochim/fisiol
Eukaryotic translation initiation factor 2-α kinase 4 (EIF2AK4) is responsible for phosphorylation of the a subunit of the eukaryotic initiation factor 2 (eIF2α). The EIF2AK4 eIF2-α kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. The protein p58IPK inhibits EIF2AK4 activity. EIF2AK4 is linked to pulmonary veno-occlusive disease (PVOD) development and its pathway is associated with diseases such as cancer and Alzheimer′s disease. The protein affects many aspects of cellular physiology in response to a number of stresses such as starvation. Mutation in EIF2AK4 may cause autosomal-recessive pulmonary capillary hemangiomatosis (PCH). EIF2AK4 causes tumor growth and angiogenesis by expression of vascular endothelial growth factor (VEGF).
Stato fisico
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Nota sulla preparazione
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Note legali
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
EIF2AK4 mutations in pulmonary capillary hemangiomatosis
D Hunter Best
Chest, 145 (2013)
Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase
J J Berlanga
European Journal of Biochemistry (2014)
p58IPK is an inhibitor of the eIF2a kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity.
Anne Roobol
The Biochemical Society, 465 (2014)
mino acid deprivation promotes tumor angiogenesis through the GCN2/ATF4 pathway
Yugang Wang
Neoplasia (2013)
EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension
Melanie Eyries
Nature Genetics, 46(46) (2013)
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