SRP5156
14-3-3 ζ, untagged human
recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sinonimo/i:
14-3-3 ζ, KCIP-1, MGC111427, MGC126532, MGC138156, YWHAZ
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About This Item
Prodotti consigliati
Origine biologica
human
Ricombinante
expressed in E. coli
Saggio
≥70% (SDS-PAGE)
Forma fisica
buffered aqueous glycerol solution
PM
~29 kDa
N° accesso NCBI
applicazioni
cell analysis
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
Informazioni sul gene
human ... YWHAZ(7534)
Descrizione generale
14-3-3ζ (also known as tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide) is a member of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3ζ protein plays a key role in cancer biology by being an important regulator of major cellular processes such as proliferation, differentiation, senescence and apoptosis. 14-3-3ζ protein has been shown to interact with the IRS1 protein, suggesting a role for this protein in regulating insulin sensitivity by interrupting the association between the insulin receptor and IRS1.
Stato fisico
Supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Nota sulla preparazione
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
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Zenggang Li et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(1), 162-167 (2007-12-29)
The family of 14-3-3 proteins has emerged as critical regulators of diverse cellular responses under both physiological and pathological conditions. Here, we report an important role of 14-3-3zeta in tumorigenesis through a mechanism that involves anoikis resistance. 14-3-3zeta is up-regulated
M Niemantsverdriet et al.
Oncogene, 27(9), 1315-1319 (2007-08-21)
14-3-3 proteins are relevant to cancer biology as they are key regulators of major cellular processes such as proliferation, differentiation, senescence and apoptosis. So far, the sigma isoform (14-3-3sigma) has most directly been implicated in carcinogenesis and was recognized as
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