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Documenti fondamentali

SRP4121

Sigma-Aldrich

IGF-I from rat

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

Sinonimo/i:

IGF-I, IGF1, IGFIA, Somatomedin C

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About This Item

Numero MDL:
MFCD00081716
Codice UNSPSC:
12352202
NACRES:
NA.32

Origine biologica

rat

Ricombinante

expressed in E. coli

Saggio

≥95% (HPLC)
≥95% (SDS-PAGE)

Forma fisica

lyophilized

PM

~7.69 kDa

Confezionamento

pkg of 20 μg

Condizioni di stoccaggio

avoid repeated freeze/thaw cycles

Impurezze

endotoxin, tested

N° accesso NCBI

P08025

N° accesso UniProt

P08025

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

rat ... Igf1(24482)

Descrizione generale

IGF-I (insulin-like growth factor-I) is a member of a family of polypeptide growth factors. Rat IGF-I is a 7.69kDa protein containing 70 amino acid residues.
IGF-I exists in two isoforms (IGF1A and IGF1B) in mouse due to alternative transcription.

Applicazioni

IGF-I (Insulin-like Growth Factor-I) from rat has been used to study the the effect of IGF-I, IL-27 (interleukin-27) and IL-35 on the blood flow in the inflamed joints of rats.
IGF-I from rat has also been used to test its effect on the expression of its receptor in rheumatoid arthritis model.

Azioni biochim/fisiol

IGF-I (Insulin-like growth factor-I) is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It mainly mediates growth and development. IGF-I is required for fetal growth and development. It is also involved in the growth and repair of heart tissues. IGF-I has been linked to neuroplasticity and hippocampal neurogenesis. It is important in the recovery from ischaemic injury.
IGF-I interacts with interleukins IL-27 and IL-35 and may play a role in chronic joint inflammation.

Stato fisico

Lyophilized without additives.

Ricostituzione

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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SILu™Prot IGF-1, Insulin Growth Factor -1 human recombinant, expressed in E. coli, SIL MS Protein Standard, 15N-labeled

Sigma-Aldrich

MSST0063

SILu™Prot IGF-1, Insulin Growth Factor -1 human

Tacrolimus monohydrate European Pharmacopoeia (EP) Reference Standard

Y0001926

Tacrolimus monohydrate

AMD3100 octahydrochloride hydrate ≥97% (NMR), solid

Sigma-Aldrich

A5602

AMD3100 octahydrochloride hydrate

Insulina, umana ricombinante for research or for further manufacturing use, dry powder

SAFC

91077C

Insulina, umana ricombinante

The effect of interleukins 27 and 35 and their role on mediating the action of insulin Like Growth Factor -1 on the inflammation and blood flow of chronically inflamed rat knee joint.
Houshmandi N
Cytokine, 81, 117-126 (2016)
Glucose metabolism and hepatic Igf1 DNA methylation are altered in the offspring of dams fed a low-salt diet during pregnancy.
Siqueira FR
Physiology & Behavior, 154, 68-75 (2016)
Aimee J Varewijck et al.
European journal of endocrinology, 173(2), 119-127 (2015-05-08)
Previously we demonstrated that IGF1 receptor stimulating activity (IGF1RSA) offers advantages in diagnostic evaluation of adult GH deficiency (GHD). It is unknown whether IGF1RSA can be used to monitor GH therapy. To investigate the value of circulating IGF1RSA for monitoring
María Llorens-Martín et al.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 15(2), 134-148 (2009-03-25)
This review addresses the role of serum insulin-like growth factor 1 (IGF1) as one mechanism of adult neural plasticity, specifically, its regulation of hippocampal neurogenesis among other plasticity-related processes. It is suggested that IGF has been reused advantageously both for
He He et al.
Inflammation, 38(6), 2178-2184 (2015-06-25)
Sepsis-induced myocardial injury (SIMI) is caused by various mechanisms. The aim of this study was to investigate the effects of salidroside (Sal) on SIMI and its mechanisms in rats. The sepsis model was established by intraperitoneal injection of lipopolysaccharide (LPS)
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