SML3120

LY272015

≥98% (HPLC)

• Sinonimo/i: 1-[(3,4-Dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole monohydrochloride, 1H-Pyrido[3,4-b]indole, 1-[(3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-, hydrochloride (1:1), LY 272015, LY-272015
• Formula empirica (notazione di Hill): C₂₁H₂₄N₂O₂ · HCl
• Numero CAS: 172895-15-7
• Peso molecolare: 372.89
• Numero MDL: MFCD00933882
• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Colore: white to beige
• Solubilità: DMSO: 2 mg/mL, clear
• Temperatura di conservazione: −20°C
• Stringa SMILE: CC1=CC(C2=C(C(NCC2)CC(C=C3OC)=CC=C3OC)N4)=C4C=C1.Cl
• InChI: 1S/C21H24N2O2.ClH/c1-13-4-6-17-16(10-13)15-8-9-22-18(21(15)23-17)11-14-5-7-19(24-2)20(12-14)25-3;/h4-7,10,12,18,22-23H,8-9,11H2,1-3H3;1H; BKAZOTIBKRWLQA-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

LY272015 is a high-affinity, 5-HT2B subtype-selective serotonin receptor antagonist (5-HT2B -log KB = 9.86, 5-HT2A/5-HT2C -log Ki = 7.65/7.92) that exhibits antihypertensive efficacy in deoxycorticosterone acetate (DOCA)-salt-hypertensive rats in vivo (1, 3 mg/kg iv; 1x/wk for 4 wks). LY272015 inhibits mitral valve interstitial cell (MVIC) activation by 5HT in cultures (100 nM LY, 10 nM or 1 μM 5HT; canine MVIC) and ex vivo (100 μM LY, 10 μM 5HT; human MV), as well as mitigates angiotensin II infusion-provoked MV remodeling in mice in vivo (3 mg/kg via infusion by osmotic pumps 2x/wk).

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable