SML2888

LH1306

≥95% (HPLC)

• Sinonimo/i: 2,2’-Dimethyl-3,3’-bis[2-methoxy-3-(2-acetamidoethylamino)-methylpyridin-6-yl-oxymethyl]-1,1’-biphenyl, LH 1306, LH-1306, N,N′-(2,2′-(6,6′-(2,2′-Dimethylbiphenyl-3,3′-diyl)bis(methylene)bis(oxy)bis(2-methoxypyridine-6,3-diyl))bis(methylene)bis(azanediyl)bis(ethane-2,1-diyl))diacetamide
• Formula empirica (notazione di Hill): C₃₈H₄₈N₆O₆
• Numero CAS: 2182653-84-3
• Peso molecolare: 684.82
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95% (HPLC)
• Stato: powder
• Colore: white to beige
• Solubilità: DMSO: 2 mg/mL, clear
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: -10 to -25°C

Descrizione

Azioni biochim/fisiol

LH1306 is a potent programmed cell death-1/programmed death-ligand 1 (PD-1 (CD279, PDCD1)/PD-L1 (B7-H1, PDCD1-L1)) protein-protein interaction (PPI) inhibitor (IC50 = 25 nM by HTRF assay) that induces symmetrically arranged PD-L1 homodimer formation by targeting PD-L1 at the PD-1 binding site. LH1306 effectively blocks cell surface PD-1/PD-L1 interaction between PD-1-expressing Jurkat cells and co-cultured PD-L1-expressing U2OS cells (SHP-1 recruitment IC50 = 334 nM) or co-cultured PD-L1-expressing aAPC/CHO-K1 cells (NFAT signaling restoration EC50 = 4.21 μM).

Potent programmed cell death-1 (PD-1, CD279, PDCD1)/PD-1 ligand (PD-L1, B7-H1, PDCD1-L1) protein-protein interaction (PPI) inhibitor.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable