SML1518

SID 3712249

≥95% (HPLC)

• Sinonimo/i: 1,8-Diamino-3,6-di-1-pyrrolidinyl-2,7-naphthyridine-4-carbonitrile, MLS000054131, MiR-544 Inhibitor 1
• Formula empirica (notazione di Hill): C₁₇H₂₁N₇
• Numero CAS: 522606-67-3
• Peso molecolare: 323.40
• Numero MDL: MFCD03483890
• Codice UNSPSC: 12352200
• ID PubChem: 329825935
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95% (HPLC)
• Forma fisica: powder
• Condizioni di stoccaggio: protect from light
• Colore: white to brown
• Solubilità: DMSO: 15 mg/mL, clear
• Temperatura di conservazione: room temp
• Stringa SMILE: NC1=C2C(C=C(N3CCCC3)N=C2N)=C(C#N)C(N4CCCC4)=N1
• InChI: 1S/C17H21N7/c18-10-12-11-9-13(23-5-1-2-6-23)21-15(19)14(11)16(20)22-17(12)24-7-3-4-8-24/h9H,1-8H2,(H2,19,21)(H2,20,22); SSWVPYMSHHEYAB-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

SID 3712249 (MiR-544 Inhibitor 1) is an inhibitor of the biogenesis of microRNA-544 (miR-544). MiR-544 represses expression of mTOR, promoting tumor cell survival in a hypoxic environment. Inhibition of miR-544 processing with MiR-544 Inhibitor 1 caused apoptosis in triple negative breast cancer cells in response to hypoxic stress, sensitized their response to 5-fluorouracil, and blocked their growth after transplantion into immunodeficient mice. SID 3712249 (MiR-544 Inhibitor 1) is believed to bind directly to the precursor miRNA, blocking production of the mature microRNA and resulting in decreased miR-544, HIF-1α, and ATM transcripts. MiR-544 Inhibitor 1 was as selective and 25-fold more potent than a 2′-O-methyl RNA antagomir.

Altre note

light sensitive

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable