SML0943
YM-1
Sinonimo/i:
2-[[3-Ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-1-methyl-pyridinium chloride
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About This Item
Formula empirica (notazione di Hill):
C20H20ClN3OS2
Numero CAS:
Peso molecolare:
417.98
Codice UNSPSC:
12352200
NACRES:
NA.77
Prodotti consigliati
Saggio
≥98% (HPLC)
Livello qualitativo
Forma fisica
powder
Colore
orange to dark red
Solubilità
H2O: 2 mg/mL, clear (warmed)
Temperatura di conservazione
2-8°C
Applicazioni
YM-1 has been used as a Hsp70 (heat shock protein) inhibitor in cell viability assay.
Azioni biochim/fisiol
YM-1 modulates Hsp70 activity by binding to the nucleotide-binding domain of ADP- but not ATP-bound Hsp70, stabilizing Hsp70 in its ADP-bound conformation. The ADP-bound state has tight affinity for its substrates, promoting their ubiquitination and degradation, and a greatly reduced off rate compared to the ATP-bound state. YM-1 appears to behave in a similar manner to Hip, a Hsp70 co-chaperone that stabilizes Hsp70 in its ADP-bound conformation which favors degradation of misfolded substrates such as those involved in various neurodegenerative diseases.
YM-1 also has anticancer activity, which could be due to enhanced ubiquitination and clearance of Akt, a major survival kinase. In studies with multiple cancer lines, YM-1 was found to selectively target cancer cells over normal cells and to overcome tamoxifen resistance in a tamoxifen-resistant MCF7 cell model. YM-1 had greater efficacy and cytosolic localization than the closely related MKT-077 (M5449).
YM-1 also has anticancer activity, which could be due to enhanced ubiquitination and clearance of Akt, a major survival kinase. In studies with multiple cancer lines, YM-1 was found to selectively target cancer cells over normal cells and to overcome tamoxifen resistance in a tamoxifen-resistant MCF7 cell model. YM-1 had greater efficacy and cytosolic localization than the closely related MKT-077 (M5449).
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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I clienti hanno visto anche
Effect of an Inhibitor of HSP70, YM-1, on Hikeshi Knockout Cells.
RAHMAN K Z, et al.
Japanese Society for Thermal Medicine, 33(4), 117-122 (2017)
Chieh-Ting Fang et al.
Cell death & disease, 11(8), 715-715 (2020-09-03)
The heat shock protein 70 (HSP70) is a conserved molecular chaperone and proteostasis regulator that protects cells from pharmacological stress and promotes drug resistance in cancer cells. In this study, we found that HSP70 may promote resistance to anticancer drugs
Ayushman Ghosh et al.
Intervirology, 60(6), 247-262 (2018-06-29)
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