SML0723

ML252

≥98% (HPLC)

• Sinonimo/i: (S)-2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide
• Formula empirica (notazione di Hill): C₂₀H₂₄N₂O
• Numero CAS: 1392494-64-2
• Peso molecolare: 308.42
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Colore: , light to dark purple
• Solubilità: DMSO: 25 mg/mL, clear
• Temperatura di conservazione: 2-8°C

Descrizione

Azioni biochim/fisiol

ML252 is a potent, brain penetrant potassium channel Kv7.2 (KCNQ2) inhibitor with an IC₅₀ of 69 nM. ML252 is only slightly selective over KCNQ3 and KCNQ4 but is over 40-fold selective for KCNQ2 vs KCNQ1, unlike other KCNQ inbhibitors currently used. ML252 was also selective vs. >68 tested GPCRs, ion channels, and transporters. Potassium channel Kv7.2 has become a new target for Alzheimer′s Disease drug research because inhibiting it enhances acetylcholine release. SAR studies showed a small structural change from ethyl group to hydrogen resulted in a functional shift from antagonist to agonist activity (37, EC₅₀ of 170 nM), suggesting an interaction at a critical site for controlling KCNQ2 channel gating.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable