SML0472
4-IPP
≥97% (HPLC)
Sinonimo/i:
4-Iodo-6-phenylpyrimidine
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About This Item
Formula empirica (notazione di Hill):
C10H7IN2
Numero CAS:
Peso molecolare:
282.08
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77
Prodotti consigliati
Saggio
≥97% (HPLC)
Forma fisica
powder
Colore
white to beige
Solubilità
DMSO: 10 mg/mL (clear solution, warmed)
Temperatura di conservazione
−20°C
Stringa SMILE
Ic1cc(ncn1)-c2ccccc2
InChI
1S/C10H7IN2/c11-10-6-9(12-7-13-10)8-4-2-1-3-5-8/h1-7H
ZTCJXHNJVLUUMR-UHFFFAOYSA-N
Applicazioni
4-IPP has been used as a macrophage migration inhibitory factor (MIF) in conditioned medium (CM) for in vitro migration assay.
Azioni biochim/fisiol
4-IPP is a cell permeable, potent macrophage migration inhibitory factor (MIF) antagonist that covalently modifies MIF N-terminal proline.
4-Iodo-6-phenylpyrimidine (4-IPP) has the potential to be a new anti-polyploid therapeutic agent that may be utilized in patients with thyroid cancer to target polyploid tumor cells. It suppresses osteoclastogenesis by blocking the IMF-κB pathway. 4-IPP can be employed as a therapeutic target for macrophage migration inhibitory factor (MIF) to treat pathologic osteolytic bone diseases and postmenopausal bone loss. It can prevent the development and motility of lung adenocarcinoma cells and can stimulate apoptosis and mitotic death of thyroid carcinomas.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
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