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Merck
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Documenti fondamentali

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SML0400

Sigma-Aldrich

ML204

≥98% (HPLC)

Sinonimo/i:

4-Methyl-2-(1-piperidinyl)-quinoline

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About This Item

Formula empirica (notazione di Hill):
C15H18N2
Numero CAS:
5465-86-1
Peso molecolare:
226.32
Numero MDL:
MFCD00817920
Codice UNSPSC:
12352200
ID PubChem:
329825396
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

white to beige

Solubilità

DMSO: 5 mg/mL at warmed (clear solution)

Temperatura di conservazione

2-8°C

Stringa SMILE

Cc1cc(nc2ccccc12)N3CCCCC3

InChI

1S/C15H18N2/c1-12-11-15(17-9-5-2-6-10-17)16-14-8-4-3-7-13(12)14/h3-4,7-8,11H,2,5-6,9-10H2,1H3
USYRQXDHKXGTCK-UHFFFAOYSA-N

Applicazioni

4-methyl-2-(1- piperidinyl)-quinoline (ML204) has been used to attenuate Ewing sarcoma (EWS)-FLI1 activity in TC32 cells. It has also been used to attenuate scratching behavior evoked by α-Me-5HT in mice.

Azioni biochim/fisiol

ML204 is a potent and selective TRPC4 channel inhibitor.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Peng Sun et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 34(12), 2164-2172 (2017-09-25)
A novel carboxylated multi-walled carbon nanotubes (MWCNTs-COOH) dispersive solid phase extraction (d-SPE) method combined with gas chromatography (GC) with an electron capture detector (ECD) was developed for the determination of seven pyrethroid pesticides in cucumber, spinach, eggplant, tomato and carrot.
Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice
Lee SH, et al.
The Journal of Allergy and Clinical Immunology, 142(4), 1349-1352 (2018)
Stephanie D Jones et al.
Zoology (Jena, Germany), 118(6), 439-445 (2015-08-25)
The phenotype-linked fertility hypothesis proposes that secondary sexual characters (SSCs) advertise a male's fertility to prospective mates. However, findings from empirical studies attempting to test this hypothesis are often ambivalent or even contradictory, and few studies have simultaneously evaluated how
Domingos M S Pereira et al.
Oxidative medicine and cellular longevity, 2018, 4904696-4904696 (2018-07-10)
Thioredoxin plays an essential role in bacterial antioxidant machinery and virulence; however, its regulatory actions in the host are less well understood. Reduced human Trx activates transient receptor potential canonical 5 (TRPC5) in inflammation, but there is no evidence of
Englerin A inhibits EWS-FLI1 DNA binding in Ewing sarcoma cells
Caropreso V, et al.
The Journal of Biological Chemistry, 291(19), 10058-10066 (2016)
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